ABOUT US
MISSION / VISION



ABOUT US

The Center for Biomarkers in Imaging is an academic, non-profit organization dedicated to the identification, characterization and validation of biomarkers. Founded in April 2001, the Center is based within the Department of Radiology at the Massachusetts General Hospital. Located in downtown Boston, the hospital is a major teaching affiliate of Harvard Medical School. CBI has also joined forces with the Harvard-MIT Division of Health Sciences and Technology (HST), facilitating research collaborations and educational opportunities between CBI and HST, as well as the Harvard and MIT communities at large.


MISSION / VISION

The Center for Biomarkers in Imaging (CBI) at MGH and HST is a non-profit, academic organization dedicated to the identification, characterization and validation of image-related biomarkers, defined as anatomic, physiologic, biochemical, or molecular parameters associated with the presence and severity of specific disease states. Built on extensive imaging experience, the Center for Biomarkers in Imaging will gather, catalog, and maintain an extensive, easily accessible database on biomarkers, to be shared with academia, government and industry. Through this process, CBI will promote the application of biomarkers as pre-clinical and clinical endpoints in the evaluation of new drugs and medical devices, ultimately resulting in more accurate, timely and transparent regulatory decisions.

The Center for Biomarkers in Imaging draws on both MGH Radiology’s, as well as Harvard-MIT HST’s, extensive experience in working with industry, academia and the government to successfully employ imaging-related biomarkers in both the pre-clinical and clinical arenas. Examples may be found by selecting an area of experience below:

Biomarkers
Diseases


BIOMARKERS
Biliary ductal dilatation Intra-arterial thrombus Neurotransmitter uptake and binding
Body fat composition Intravenous thrombus Osseous fusion
Bone marrow composition Lesion volume/brain Osseous metastases, presence of
Bone mineral density Lesion volume/colon Periarticular erosion
Cartilage volume Lesion volume/head and neck Pulmonary metastases, presence of
Cerebral diffusion/perfusion Lesion volume/liver Protein synthesis
Cerebral infarct size Lesion volume/lung Renal stones, presence of
CNS demyelination Lesion volume/pancreas Tissue perfusion
Endometrial thickness Lesion volume/ovarian Tumor metabolic activity
Fat content of bone marrow Liver tissue characterization Vertebral body height
Hydronephrosis Lymph node metastases, presence of


DISEASES
Arterial thrombus Glioblastoma multiforme Multiple Sclerosis
Biliary strictures Gynecological malignancy Obesity
Cholangitis Head and neck cancer Osteoporosis
Cholangiocarcinoma Hepatic hemangioma Ovarian cancer
Cholelithiasis Hepatocellular carcinoma Pancreatitis
Colon cancer Infection Pancreatic cancer
Deep venous thrombosis Ischemic stroke Parkinson’s Disease
Diabetes Lung cancer Prostate cancer
Focal nodular hyperplasia Lymphoma Rheumatoid arthritis
Focal splenic lesions Metastatic breast cancer Spinal fusion
Gaucher’s Disease Metastatic colon cancer Stroke