| Disease Category |
Disease/ Medical Condition |
Biomarker |
Imaging Technique |
Investigators |
Comments |
Cardiology / Vascular |
Acute myocardial infarction
|
Intravascular thrombus |
MRI |
Brady T |
|
| Cardiology / Vascular |
Alveolar pulmonary edema |
Pulmonary consolidation |
CT
MRI |
McLoud TC
Shepard J
|
|
| Cardiology / Vascular |
Aortic aneurysm |
Vascular diameter, circumference
|
US
CT
MRI
|
Waltman A |
|
| Cardiology / Vascular |
Aortic dissection |
Anatomic disruption of arterial wall
|
US
CT
MRI Angiography
|
Gonzalez RG
Waltman A
|
|
| Cardiology / Vascular |
Arterial embolism |
Intravascular thrombus |
CT
MRI
Angiography
|
Waltman A |
|
| Cardiology / Vascular |
Deep venous thrombosis |
Intravascular thrombus |
US
MRI
Angiography
|
O’Neill MJ
Waltman A
|
|
| Cardiology / Vascular |
Dissection, peripheral |
Vascular diameter, lumen |
CT
MRI
Angiography
|
Waltman A |
|
| Cardiology / Vascular |
Iliac aneurysm |
Vascular diameter, circumference
|
US
CT
MRI
|
Waltman A |
|
| Cardiology / Vascular |
Interstitial pulmonary edema |
Increased pulmonary interstitial markings
|
CT |
McLoud TC
Shepard J
|
|
| Cardiology / Vascular |
Ischemic Heart Disease |
Myocardial blood flow via 13N-Ammonia |
Nuclear medicine SPECT
|
Fischman AJ |
|
| Cardiology / Vascular |
Pulmonary embolism |
Embolism volume |
MRI |
Weissleder R |
via monocrystalline iron oxide nanoparticles (MION)
|
| Cardiology / Vascular |
Pulmonary embolism |
Intravascular thrombus
|
CT |
McLoud TC
|
|
| Cardiology / Vascular |
Pulmonary embolism |
Ventilation/perfusion mismatch
|
Nuclear medicine |
Fischman AJ |
|
| Cardiology / Vascular Neurological Metabolic |
Arteriosclerosis, peripheral |
Vascular diameter, lumen |
CTA
MRA Angiography |
Gonzalez RG
Hunter G
Lev M
Waltman A
|
|
Cardiology / Vascular Neurological Metabolic
|
Atherosclerosis, central |
Arterial calcification |
CT |
Brady T |
|
Cardiology / Vascular Metabolic
|
Coronary artery disease |
Arterial calcification |
CT |
Brady T |
|
| Cardiology / Vascular Metabolic |
Coronary artery disease |
Myocardial blood flow via 13N-Ammonia
|
Nuclear Medicine SPECT |
Fischman AJ |
|
| Cardiology / Vascular Metabolic |
Coronary artery disease |
Myocardial contractility/function
|
MRI
Nuclear Medicine |
Brady T
Fischman AJ
|
|
| Cardiology / Vascular Metabolic |
Coronary artery disease |
Myocardial ischemia/infarction |
MRI
Nuclear Medicine |
Brady T
Fischman AJ
|
|
| Cardiology / Vascular Metabolic |
Coronary artery disease |
Myocardial perfusion |
Nuclear medicine |
Fischman AJ |
|
| Cardiology / Vascular Gastrointestinal |
Portal vein thrombosis |
Intravascular thrombus |
US
CT
MRI Angiography |
Hahn P
Mueller P
O’Neill MJ
Waltman A
|
|
Cardiology / Vascular Inflammatory Infectious Disease Endocrine Metabolic
|
Myocarditis |
Myocardial ischemia/infarction |
MRI |
Brady T |
|
Cardiology / Vascular Inflammatory Infectious Disease Endocrine Metabolic
|
Myocarditis |
Myocardial ischemia/infarction |
Nuclear Medicine |
Fischman AJ |
|
Endocrine
Infectious disease
Metabolic
Musculoskeletal
|
HIV lipodystrophy syndrome
Diabetes (Type II)
Obesity |
Intramyocellular lipid levels |
Proton MR spectroscopy |
Torriani M |
|
Endocrine Inflammatory Infectious Disease Cardiology / Vascular
|
Myopathy |
Soft Tissue inflammation |
MRI |
Palmer W
Rosenthal DI
|
|
Endocrine Inflammatory Gstrointestinal Metabolic
|
Choledocholithiasis |
Biliary ductal dialation |
US
CT
MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Endocrine Inflammatory Gstrointestinal Metabolic
|
Cholelithiasis |
Gallstones |
US
CT
MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
| Endocrine Metabolic Inflammatory |
Allegric Drug reaction |
Increased pulmonary interstitial markings |
CT |
McLoud TC
Shepard J
|
|
Endocrine Metabolic Musculoskeletal Infectious Disease Gastrointestinal
|
AIDS wasting syndrome |
Body Fat Composition |
CT |
Rosenthal DI |
|
Endocrine Gasrtointestinal
|
Calculus Disease |
MR Cholangio- pancreatography |
MRI |
Sahani D
Prasad S
|
|
Endocrine Metabolic Musculoskeletal
|
Osteoporosis |
Bone mineral density |
Plain Radiographs DEXA CT |
Rosenthal DI |
Must establish bone strength as well as density |
| Endocrine Metabolic Musculoskeletal |
Oteopenia |
Bone mineral density |
Plain Radiographs DEXA CT |
Rosenthal DI |
Must establish bone strength as well as density
|
Endocrine Metabolic Musculoskeletal Gastrointestinal
|
Obesity |
Body Fat Composition |
|
|
|
Endocrine Musculoskeletal Metabolic
|
Crystalline Disease |
Periarticular erosion |
Plain Radiographs MRI |
Palmer W
Rosenthal DI
|
|
Endocrine Inflammotory Infectious Disease Gastrointestinal
|
Cholecystitis |
Gallstones, gallbladder wall thickening |
US
CT
MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
| Endocrine Metabolic Gastrointestinal |
Pancreatic Function |
Acinar cell receptor binding |
MRI |
Brady TJ
Shen TT
Weissleder R
|
Secretin MION |
| Gastrointestinal |
Biliary obstruction |
Biliary ductal dilatation |
US
CT
MRI
|
Hahn P
Mueller P
|
|
| Gastrointestinal |
Biliary stricture |
Magnetic Resonance Cholangiopancreatography |
MRI |
Prasad S
Sahani D
Saini S
|
|
| Gastrointestinal |
Gastrointestinal Bleeding |
Intraluminal hemorrhage
|
SPECT |
Fischman AJ |
|
| Gastrointestinal |
Hepatic cysts |
Liver tissue characterization |
MRI (using superparamagnetic iron oxide, mangafodipir trisodium, ultrasmall superparamagnetic iron oxide)
|
Hahn P
Harisinghani M
Mueller P
Weissleder R
|
|
| Gastrointestinal |
Hepatobiliary disorders |
Liver tissue characterization |
MRI |
Hahn P
Harisinghani M
Mueller P
Weissleder R
|
using superparamagnetic iron oxide, mangafodipir trisodium, ultrasmall superparamagnetic iron oxide
|
Gastrointestinal Genitourinary Infectious Disease
|
Intra-abdominal abscess |
Cyst composition/tissue characterization |
US
CT
MRI |
Mueller P |
Must establish bone strength as well as density |
| Gastrointestinal Cardiology / Vascular |
Splenic trauma |
Splenic tissue characterization |
MRI |
Hahn P
Harisinghani M
Mueller P
Weissleder R
|
using ultrasmall superparamagnetic iron oxide |
Gastrointestinal Inflammatory Metabolic Infectious Disease
|
Pancreatitis |
Chemotactic peptide uptake |
SPECT |
Fischman AJ |
Via 99mTc labeled peptide analog
|
Gastrointestinal Inflammatory Metabolic Infectious Disease
|
Pancreatitis |
Ductal irregularity or obstruction |
MRI |
Prasad S
Sahani D
Saini S
|
visualized by Cholaniopancreatography |
Gastrointestinal Infectious Disease
|
Biliary parasitic disease |
Biliary ductal dilatation |
US
CT
MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Gastrointestinal Infectious Disease Inflammatory
|
Cholangitis |
Magnetic Resonance Cholangiopancreatography |
MRI |
Prasad S
Sahani D
Saini S
|
|
| Infectious Disease |
HIV |
Directed molecular probes
|
MRI
PET Optical
|
Weissleder R |
|
| Infectious Disease |
Pneumonia |
Pulmonary consolidation |
CT
MRI |
Mcloud TC
Shepard J
|
|
| Infectious Disease |
Pulmonary infection |
Increased pulmonary interstitial markings |
CT |
Mcloud TC
Shepard J
|
|
Infectious Disease Inflammatory
|
Pneumonitis |
Pulmonary consolidation |
CT
MRI |
Mcloud TC Shepard J |
|
Infectious Disease Musculoskeletal Inflammatory
|
Septic arthritis |
Cyst composition/ tissue characterization |
PET |
Palmer W
Rosenthal DI
|
|
Infectious Disease Musculoskeletal Inflammatory
|
Septic arthritis |
Increased synovial glucose metabolism |
MRI |
Palmer W
Rosenthal DI
|
|
Infectious Disease Musculoskeletal Inflammatory
|
Septic arthritis |
Synovial thickening |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Infectious Disease Musculoskeletal Inflammatory
|
Soft tissue infection |
Leukocyte accumulation |
Nuclear medicine |
Fischman AJ |
|
Infectious Disease Musculoskeletal Inflammatory
|
Soft tissue infection |
Osteoblastic activity |
Nuclear medicine |
Fischman AJ |
|
Infectious Disease Musculoskeletal Inflammatory
|
Soft tissue infection |
Soft tissue inflammation |
MRI Nuclear Medicine |
Fischman AJ
Palmer W
Rosenthal DI
|
|
Infectious Disease Musculoskeletal
|
Osteomyelitis |
Leukocyte accumulation |
Nuclear medicine |
Fischman AJ |
|
| Inflammatory |
Connective tissue disorders |
Increased pulmonary interstitial markings |
CT |
McLoud TC
Shepard J
|
|
| Metabolic |
Diabetes |
Beta Cell Mass
|
Optical |
Weissleder R
|
|
| Musculoskeletal |
Synovial chondromatosis |
Periarticular erosion |
Plain radiographs MRI |
Palmer W
Rosenthal DI
|
|
| Musculoskeletal |
Synovial cyst |
Cyst composition/ tissue characterization
|
US
CT
MRI
|
Rosenthal DI
|
|
| Musculoskeletal Inflammatory |
Osteoarthritis |
Articular cartilage thickness
|
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory
|
Osteoarthritis |
Osteoblastic activity |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal Inflammatory
|
Trauma |
Soft tissue inflammation |
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory
|
Trauma |
Soft tissue inflammation |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal Infectious Disease
|
Osteomyelitis |
Leukocyte accumulation |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal Inflammatory
|
Ganglion cyst |
Cyst composition/ tissue characterization |
US, CT, MRI |
Rosenthal DI |
|
Musculoskeletal Inflammatory
|
Inflammatory arthritis |
Articular cartilage thickness |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory
|
Inflammatory arthritis |
Increased synovial glucose metabolism |
PET |
Fischman AJ
Palmer W
Rosenthal DI
|
|
| Musculoskeletal Inflammatory |
Inflammatory arthritis |
Periarticular erosion |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
| Musculoskeletal Inflammatory |
Inflammatory arthritis |
Synovial thickening |
MRI |
Palmer W
Rosenthal DI
|
|
| Musculoskeletal Inflammatory |
Rheumatoid arthritis |
Articular cartilage thickness |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory Infectious Disease
|
Soft tissue infection |
Soft tissue inflammation |
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory Metabolic
|
Amyloid arthropathy |
Periarticular erosion |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
| Musculoskeletal Metabolic |
Fracture healing |
Osseous bridging |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Metabolic
|
Fracture healing |
Osteoblastic activity |
Nuclear medicine |
Fischman AJ. |
|
| Neurological |
Anorexia |
rCBF |
PET |
Alpert N
Fischman AJ
Rauch SL
|
|
| Neurological |
Asphyxia |
Altered vascular and tissue permeability |
CT |
Gonzalez RG
Grant E
|
|
| Neurological |
Asphyxia |
Early diffusion changes |
DWI |
Grant E
Schaefer P
Sorensen AG
|
|
| Neurological |
Asphyxia |
Lac :Cho ratio |
MRS |
Jenkins B
|
|
| Neurological |
Attention deficit hyperactivity disorder (ADHD) |
ACCD activation (anterior cingulate cortex division) |
fMRI PET |
Bush G
Fischman AJ
Rosen BR
|
|
| Neurological |
Attention deficit hyperactivity disorder (ADHD)
|
Cortical thickness and assymetry |
MRI (morphometry) |
Kennedy D |
|
| Neurological |
Attention deficit hyperactivity disorder (ADHD)
|
Dopamine transporter density |
SPECT |
Fischman AJ
Rauch SL
|
|
| Neurological |
Autism |
Frontal language area |
MRI |
Caviness VS
Harris G
Kennedy D
|
Reversal of morphometric asymmetry in frontal language area
|
| Neurological |
Autism |
Frontal language area |
fMRI |
Harris G |
Abnormal fMRI activation of frontal languag areas during semantic language tasks
|
| Neurological |
Brain Development -Anencephaly -Microcephaly -Holoprosencephaly
|
Cortical thickness, volume, location |
MRI morphometry fMRI |
Caviness VS
Dale A
Fischl B
Kennedy D
|
|
| Neurological |
Brain Function / Neuronal Content |
NAA Images |
MRI chemical shift EPI |
Gonzalez RG
Jenkins B
Rosen BR
|
|
| Neurological |
Brain Function / Mapping Dopaminergic neurotransmitter activity
|
rCBF rCBV |
Pharmacologic MRI PET
fMRI |
Bogdanov M
Chen YC
Jenkins B
Rosen BR
|
using D-amphetamine and CFT |
| Neurological |
Brain Injury |
Restricted water mobility |
DWI
ADC |
Huisman TA
Gonzalez RG
Schaefer P
Sorensen AG
|
Cytotoxic edema , Vasogenic edema and diffuse axonal injury |
| Neurological |
Brain Injury / Toxicity / Trauma
|
Focal atrophy |
MRI |
Caviness VS
Kennedy D
|
|
| Neurological |
CNS AIDS fungal and opportunistic infections
|
focal brain uptake |
PET SPECT |
Fischman AJ |
Ga, Tl, FDG |
| Neurological |
CNS AIDS neuroinflammation neurodegeneration
|
NAA Cho MI |
MRS |
Gonzalez R
Schaefer P
Schwamm LH
|
|
| Neurological |
Dementia |
Blood oxygen level depletion |
fMRI |
Rosen BR
|
|
| Neurological |
Dementia |
CBF |
MRI/ASL |
Hoge R
|
|
| Neurological |
Epilepsy |
Cortical dysplasia |
MRI/ MEG fMRI |
Dale A
Grant E
Mandeville J
Rosen BR
Stufflebeam SM
Wald LL
|
|
| Neurological |
Epilepsy |
Hyperperfusion, CBF
|
MRI/ASL |
Hoge R
Kwong K
|
|
| Neurological |
Epilepsy |
NAA lateralization |
MRS |
Jenkins BG
|
|
| Neurological |
Epilepsy |
Seizure focus |
MEG/EEG |
Halgren E
Stufflebeam SM
|
|
| Neurological |
Huntinton's Disease |
Cortical thickness |
fMRI
MRI
morphometry |
Dale A
Fischl B
Harris G
Kennedy D
Rosas D
|
|
| Neurological |
Huntinton's Disease |
Basal Ganglia/ Putamen volume |
MRI |
Harris G |
|
| Neurological |
Huntinton's Disease |
Directed molecular probes |
MRI
PET Optical |
Fischman AJ
Weissleder R
|
|
| Neurological |
Huntinton's Disease |
NAA, choline:creatine ratio, Lac, |
MRS |
Jenkins BG
Rosen BR
|
|
| Neurological |
Migraine |
CBF |
Laser Speckle Contrast Imaging DOT |
Boas B Bolay
Dunn A
|
|
| Neurological |
Migraine |
CBF, CBV, MTT |
DWI/PWI fMRI |
Grant E
Schaefer P
Sorensen AG
Rosen BR
|
|
| Neurological |
Migraine |
Cortical spreading depression (CSD) |
BOLD fMRI |
Hadjikhani N
Rosen BR
Sorensen AG
|
Signal changes measured during visual aura |
| Neurological |
Migraine |
Restricted diffusion |
Optical |
Boas D
Dunn A
|
|
| Neurological |
Neurodegenerative disorders |
Apparent diffusion constant (ADC) Blood oxygen level depletion
|
fMRI
MRI/ DWI |
Jenkins BG
Kennedy D
Rosas HD
Rosen BR
|
|
| Neurological |
Obsessive Compulsive Disorder |
Cortical activation during provoked conditions
|
fMRI
PET SPECT |
Fischman AJ
Rauch SL
Rosen BR
|
|
| Neurological |
Obsessive Compulsive Disorder
|
Cortical thickness |
MRI(morphometry) |
Kennedy D |
|
| Neurological |
Obsessive Compulsive Disorder |
Whole brain morphometery |
MRI(morphometry) |
Kennedy D
Rosen BR
|
Findings include sig. Less total white-matter and greater cortex and opercular volumes
|
| Neurological |
Parkinson’s disease |
Dopamine binding potential Dopamine transporter (DAT) density
|
SPECT (using I-123 altropane) |
Fischman AJ
Halpern E
Sahani D
|
|
| Neurological |
Parkinson's Disease |
Cerebral blood volume (CBV), Cerebral blood flow (CBF)
|
MRI/ASL |
Hoge R |
|
| Neurological |
Parkinson's Disease |
Directed molecular probes
|
PET Optical |
Weissleder R |
|
| Neurological |
Parkinson's Disease |
Dopaminergic neurotransmitter activity |
fMRI
PET |
Fishman A
Livni E
Rosen BR
|
Pet using 11C-CRT |
| Neurological |
Parkinson's Disease |
NAA levels over time |
MRS |
Gonzales RG
Jenkins BG
|
|
| Neurological |
Schizophrenia |
CBF Neural activation of dorsolateral pre-frontal cortex, hippocampus and cerebellum
|
PET |
Alpert N
Fischman AJ
Heckers S
Rauch SL
Schaefer P
|
Regional activation during cognitive paradigms |
| Neurological |
Schizophrenia |
Cortical thickness |
MRI(morphometry) |
Fischl B
Harris G
Kennedy D
Kuperberg G
|
|
| Neurological |
Schizophrenia |
Specific Regional Uptake, Target selection, Functional activation
|
fMRI |
Kuperberg G
Manoach D
Stufflebeam SM
Rosen BR
|
Regional activation during cognitive paradigms |
| Neurological |
Transgenic expression |
Receptor binding Engineered transferrin receptors (ETR)
|
MRI |
Basilion JP
Hogermann D
Weissleder R
|
Probe with superparamagnetic Tf-CLIO |
| Neurological |
Visual process disorders |
Neuronal activation |
fMRI |
Mandeville JB Rosen BR Tootell RBH |
|
| Neurological |
Hepatic encephalopathy |
Glu MI NAA Lac |
MRS |
Grant E
Jenkins BG
Schaefer P
|
|
| Neurological Oncology/ Neoplasm |
CNS Neoplasm primary and secondary, presence and viability
|
Oxygen consumption CBF |
Optical |
Boas D Dunn A |
|
| Neurological Oncology/ Neoplasm |
CNS Neoplasm primary and secondary, presence and viability
|
Targeted cellular and molecular probes |
Optical MRI
PET |
Kwong KK
Weissleder R
|
Exogenous contrast agents Animal models |
| Neurological Oncology/ Neoplasm |
CNS neoplasm, primary and secondary |
Lesion Volume |
CT
MRI morphometry |
Gonzalez R
Harris G
Kennedy D
Lev
Schaefer P
Sorensen AG
|
Anatomic marker of disease presence, Response to therapy |
| Neurological Oncology/ Neoplasm |
CNS neoplasm, primary and secondary |
Microvascular blood volume and microvascular density |
fMRI
MRI |
Belliveau
Kennedy D
Rosen BR
|
|
| Neurological Oncology/ Neoplasm |
CNS neoplasm, primary and secondary |
NAA Cho Lac PCr |
MRS |
Gonzalez R
Husiman TA
Sorensen AG
|
Metabolism, Tumor viability, Response to therapy |
| Neurological Oncology/ Neoplasm |
CNS neoplasm, primary and secondary |
Tumor angiogenesis |
MRI
MRS
MRA |
Davis T
Rosen BR
Wald LL
Weissleder R
|
measured by dynamic susceptibility contrast (DSC) and monocrystalline iron oxide nanoparticles (MION)
|
| Neurological Oncology/ Neoplasm |
CNS neoplasm, primary and secondary |
Tumor growth rate |
MRI |
Bogdanov A
Marecos E
Moore A
Weissleder R
|
Serial studies of tumor voulme using uptake of long-circulatin dextran coated iron oxide (LCDIO)
|
| Neurological Oncology/ Neoplasm |
CNS Neoplasm, Schwannoma / Neurofibromatosis |
Tumor growth rate |
MRI |
Tang Y
Weissleder R
|
Transgenic murine models of neurofibromatosis |
| Neurological Oncology/ Neoplasm |
Glioma |
Tumor angiogenesis |
MRI
MRS
MRA |
Davis T
Rosen BR
Wald LL
Weissleder R
|
measured by dynamic susceptibility contrast (DSC) and monocrystalline iron oxide nan
oparticles (MION) |
| Neurological Cardiology/ Vascular |
Stroke |
Apparent diffusion constant (ADC) Relative cerebral blood flow index (rCBF)
|
DWI
fMRI
MRI (morphometry) |
Kennedy D
Lo E
Rosen BR
|
|
| Neurological Cardiology/ Vascular |
Stroke |
CBF CBV MTT Flow heterogeneity (FH) |
MRI (combined ASL and DSC) CAPTIVE |
Harris G
Hoge R
Ostergaard L
Rosen BR
Sorensen AG
Wald LL
|
MTT helps to stratify patients in clinical trials MR Perfusion Territory Imaging |
| Neurological Cardiology/ Vascular |
Stroke |
Intravascular thrombus |
CT/CTA MRI/MRA Angiography |
Caviness VS
Gonzalez RG
Schaefer P
Sorensen AG
|
|
| Neurological Cardiology/ Vascular |
Stroke |
Neuronal activation CMRO2 |
ASL MRI O2 15 PET Xenon Enhanced CT
|
Wald LL |
|
| Neurological Cardiology/ Vascular |
Stroke |
Neuronal activation CMRO2 |
fMRI DOT (NIRS) |
Boas D
Mandeville JB
Strangman G
|
NIRS agress well with fMRI, useful in longitudinal studies |
| Neurological Cardiology/ Vascular |
Stroke |
Oxygen comsumption CBF |
Optical Imaging |
Boas D
Dunn A
Lo E
|
|
| Neurological Cardiology/ Vascular |
Stroke, ischemic |
CBF rCBV water EF |
CAPTIVE MRI |
Bogdanov A
Jenkins B
Kwong K
Weissleder R
|
|
| Neurological Cardiology/ Vascular |
Stroke, ischemic |
Vascular occlusion, ischemic brain tissue |
DWI/PWI
MRI
CT perfusion
CTA |
Gonzalez R
Harris G
Sorensen AG
Wu O
|
|
| Neurological Cardiology/ Vascular |
Stroke, Recovery |
Cortical activation during sensorimotor tasks
|
fMRI |
Schaechter J
Rosen BR
|
|
| Neurological Cardiology/ Vascular |
Vulnerable plaque |
Subendothelial lipid pool |
Optical coherence tomography Near infrared spectroscopy
|
Brady T Muller J Weissleder R |
|
| Neurological Infectious Disease |
Infectious Disease -Cerebral malaria |
Diffuse cerebral adema with thalamic +/- cerebellar hypoattenuation
|
CT |
Gonzalez RG |
|
| Neurological Infectious Disease |
Infectious Disease -Empyema -Herpes virus -CJD
|
Restricted diffusion |
DWI |
Grant, E Schaefer, P |
|
Neurological Inflammatory Musculoskeletal Genitourinary Infectious Disease Gastrointestinal
|
Abscess |
Leukocyte accumulation |
SPECT |
Fischman AJ |
Tc-99m HMPAO improvement over Tl-201 and Ga-67 |
| Neurological Metabolic |
Alzheimer Disease |
CBF |
PWI/ASL |
Hoge R |
|
| Neurological Metabolic |
Alzheimer Disease |
CBF / CBV MTT |
SPECT fMRI |
Harris G
Gonzalez RG
Sorensen AG
|
|
| Neurological Metabolic |
Alzheimer Disease |
Directed molecular probes |
PET SPECT Optical |
Fischman AJ
Weissleder R
|
Animal modeling Optical with exogenous contrast agents
|
| Neurological Metabolic |
Alzheimer Disease |
Entorhinal cortex Anterior cingulate size and thickness |
MRI |
Hyman B |
Can distinguish normal from mild AD with 93% accuracy
|
| Neurological Metabolic |
Alzheimer Disease |
Hippocampal size |
MRI Quantitative volumetric morphometry |
Dale A
Hyman B
Fischl B
Kennedy D
|
|
| Neurological Metabolic |
Alzheimer Disease |
Myoinositol NAA |
MRS |
Gonzalez RG
Jenkins B
|
|
| Neurological Metabolic |
Alzheimer Disease |
Neuritic (senile) plaque |
in vivo multiphoton microscopy |
Hyman B |
Can use histochemical or immuno-fluorescence for amyloid B
|
| Neurological Metabolic |
Alzheimer Disease |
Neuronal injury |
MRI |
Gonzalez RG
|
|
| Neurological Metabolic |
Alzheimer Disease |
Oxygen utilization CBF |
Optical |
Boas D
Dunn A
|
Combining of multi-wavelength and laser speckle contrast imaging
|
| Neurological Metabolic |
Brain Development |
Oxygen consumption CBF |
Optical Imaging |
Boas D
Dunn A
|
|
| Neurological Metabolic |
Brain Function |
CBF |
MRI fMRI PET |
Belliveau
Kwong K
Rosen BR
|
Response to stimuli |
| Neurological Metabolic |
Brain Function / Drugs of Abuse |
rCMRO2 CBV |
fMRI |
Jenkins B
Kosofsky B
Mandeville JB
Rosen BR
|
Response to stimuli |
| Neurological Metabolic Cardiology/ Vascular |
Arteriosclerosis, central |
Vascular lumen diameter |
CTA MRA Angiography |
Gonzalez RG
Hunter G
Lev M
Waltman A
|
|
| Neurological Musculoskeletal |
Dyskinesia (PNKD) |
Dopa decarboxylase activity |
PET |
Fischman AJ |
|
| Neurological Oncology /Neoplasm |
CNS neoplasm, primary and secondary, presence and viability |
Glucose Metabolism |
PET |
Alpert N
Choi N
Fischman AJ
Kennedy D
Rosen BR
|
Non-specific marker with wide variety of applications |
| Neurological Cardiology/ Vascular |
Hypertension |
Relative cerebral blood volume (rCBV)
|
DSC MRI |
Hunter G
Rosen BR
|
Usind Gd-DTPA following L-arginine infusion |
| Neurological Cardiology/ Vascular |
Intracranial arterial dissection |
Anatomic disruption of arterial wall |
CTA MRA Angiography |
Gonzalez R
Lev M
Waltman A
|
|
| Neurological Inflammatory |
Multiple Sclerosis |
Comparitive brainstem analysis MS plaque demylination
|
MRI |
Jenkins B
Rosen BR
Stufflebeam SM
|
|
| Neurological Inflammatory |
Multiple Sclerosis |
Tissue characterization, Cortical thickness |
fMRI MRI morphometry |
Fischl B
Kuperberg G
|
|
| Neurological Musculoskeletal |
Pain |
Cortical activity |
fMRI PET SPECT MEG |
Fischman AJ
Halgren E
Rosen BR
Sorensen AG
Stuffelbeam SM
|
|
| Neurological Oncology/ Neoplasm |
Glioma |
Blood-tumor barrier permeability (BTP) |
MRI fMRI |
Gonzalez RG
Kwong KK
Sorensen AG
Weissleder R
|
|
| Neurological Oncology/ Neoplasm |
Glioma |
Cerebral blood volume (CBV), Cerebral blood flow (CBF)
|
MRI fMRI |
Rosen BR |
|
| Neurological Oncology/ Neoplasm |
Glioma |
Glucose Uptake |
PET |
Fischman AJ
Kennedy D
Rosen BR
|
|
| Neurological Oncology/ Neoplasm |
Glioma |
Tumor margin |
MRI |
Weissleder R |
via ultra small particulate iron oxide (USPIO)
|
| Neurological Oncology/ Neoplasm |
Glioma |
Vascular volume fraction |
Optical NMR |
Bogdanov A
Kwong KK
Weissleder R
|
Rodent Model |
| Neurological Oncology/ Neoplasm |
Head and neck carcinoma presence, primary and secondary |
Lesion Volume |
CT MRI</ |
