Disease/ Medical
Condition |
Biomarker |
Imaging
Technique |
Investigators |
Comments |
Disease Category |
Acute myocardial infarction
|
Intravascular thrombus |
MRI |
Brady T
|
|
Cardiology / Vascular |
| Alveolar pulmonary edema |
Pulmonary consolidation |
CT
MRI |
McLoud T
Shepard J
|
|
Cardiology / Vascular |
| Aortic aneurysm |
Vascular diameter and circumference |
US
CT
MRI
|
Waltman A
|
|
Cardiology / Vascular |
| Aortic dissection |
Anatomic disruption of arterial wall |
US
CT
MRI
Angiography
|
Gonzalez R
Waltman A
|
|
Cardiology / Vascular |
| Arterial embolism |
Intravascular thrombus |
CT
MRI
Angiography
|
Waltman A |
|
Cardiology / Vascular |
| Arteriosclerosis / central |
Arterial calcification |
CT |
Brady T |
|
Cardiology / Vascular Neurological Metabolic
|
| Arteriosclerosis / central |
Vascular lumen diameter |
CTA
MRA
Angiography |
Gonzalez R
Hunter G
Lev M
Waltman A
|
|
Metabolic Cardiology / Vascular |
| Arteriosclerosis / peripheral |
Lumen vascular diameter |
CTA
MRA
Angiography |
Gonzalez R
Hunter G
Lev M
Waltman A
|
|
Cardiology / Vascular Metabolic |
| Arteriosclerosis / peripheral |
Vascular lumen diameter |
CTA
MRA
Angiography
|
Gonzalez R
Hunter G
Lev M
Waltman A
|
|
Cardiology / Vascular Neurological Metabolic |
| Carotid dissection |
Anatomic disruption of arterial wall |
US CT
CTA MRI
MRA Angiography
|
Gonzalez R
Waltman A
|
|
Neurological Cardiology / Vascular |
Coronary artery disease
|
Arterial calcification |
CT |
Brady T |
|
Cardiology / Vascular Metabolic |
| Coronary artery disease |
Myocardial blood flow via 13N-ammonia
|
Nuclear medicine SPECT |
Fischman A |
|
Cardiology / Vascular Metabolic |
| Coronary artery disease |
Myocardial contractility / function |
MRI Nuclear medicine |
Brady T
Fischman A
|
|
Cardiology / Vascular Metabolic |
| Coronary artery disease |
Myocardial perfusion |
Nuclear medicine |
Fischman A |
|
Cardiology / Vascular Metabolic
|
| Deep venous thrombosis |
Intravascular thrombus |
US MRI Angiography |
O’Neill MJ
Waltman A
|
|
Cardiology / Vascular |
Dissection / peripheral
|
Vascular lumen diameter
|
CT MRI Angiography |
Waltman A |
|
Cardiology / Vascular |
| Hypertension |
Relative cerebral blood volume (rCBV)
|
Dynamic susceptibility contrast MRI
|
Hunter G
Rosen B |
Using Gd-DTPA following L-arginine infusion
|
Neurological Cardiology / Vascular |
| Iliac aneurysm |
Vascular diameter and circumference
|
US CT MRI |
Waltman A |
|
Cardiology / Vascular |
Inflammatory abdominal aortic aneurysm (IAAA)
|
Perianeurysmal fibrosis Aneurysmal wall thickness |
CT |
Brady T
Saini S
Waltman A
|
|
Inflammatory Cardiology / Vascular |
| Interstitial pulmonary edema |
Increased pulmonary interstitial markings
|
CT |
McLoud T
Shepard J
|
|
Inflammatory Cardiology / Vascular Infectious Disease
|
| Intracranial arterial dissection |
Anatomic disruption of arterial wall
|
CTA MRA Angiography |
Gonzalez R
Lev MH
Waltman A
|
|
Neurological Cardiology / Vascular |
| Ischemic heart disease |
Myocardial blood flow via 13N-ammonia
|
Nuclear medicine SPECT |
Fischman A |
|
Cardiology / Vascular |
| Myocarditis |
Myocardial function contractility Perfusion / diffusion
|
Nuclear medicine |
Fischman A |
|
Cardiology / Vascular Inflammatory Infectious Disease Endocrine Metabolic
|
| Myocarditis |
Myocardial function contractility Perfusion / diffusion |
MRI |
Brady T |
|
Cardiology / Vascular Inflammatory Infectious Disease Endocrine Metabolic
|
| Myopathy |
Soft tissue inflammation |
MRI |
Palmer W
Rosenthal DI |
|
Endocrine Inflammatory Infectious Disease Cardiology / Vascular
|
| Portal vein thrombosis |
Intravascular thrombus |
US CT MRI Angiography |
Hahn P
Mueller P
O’Neill MJ
Waltman A
|
|
Cardiology / Vascular Gastrointestinal |
| Pulmonary embolism |
Embolism volume |
MRI |
Weissleder R |
Via monocrystalline iron oxide nanoparticles (MION)
|
Cardiology / Vascular |
| Pulmonary embolism |
Intravascular thrombus
|
CT |
McLoud T |
|
Cardiology / Vascular |
| Pulmonary embolism |
Ventilation / perfusion mismatch
|
Nuclear medicine |
Fischman A |
|
Cardiology / Vascular |
| Splenic trauma |
Splenic tissue characterization |
MRI |
Harisinghani M
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide
|
Gastrointestinal Cardiology / Vascular |
| Stroke |
Apparent diffusion constant (ADC) Relative cerebral blood flow index (rCBF)
|
Diffusion weighted imaging fMRI MRI (morphometry) |
Kennedy D
Lo E
Rosen B |
|
Neurological Cardiology / Vascular |
| Stroke |
Cerebral blood flow (CBF) Cerebral blood volume (CBV) Mean transit time (MTT) Flow heterogeneity (FH)
|
MRI (combined Arterial spin labeling and dynamic susceptibility contrast) CAPTIVE
|
Harris G
Hoge R
Ostergaard L
Rosen B
Sorensen AG
Wald LL
|
MTT helps to stratify patients in clinical trials MR perfusion territory imaging |
Neurological Cardiology / Vascular |
| Stroke |
Intravascular thrombus |
CT / CTA MRI / MRA Angiography |
Caviness VS
Gonzalez RG
Schaefer P
Sorensen AG
|
|
Neurological Cardiology / Vascular |
| Stroke |
Neuronal activation CMRO2 |
Arterial spin labeling MRI O2 15 PET Xenon Enhanced CT
|
Wald LL |
|
Neurological Cardiology / Vascular |
| Stroke |
Neuronal activation CMRO2 |
fMRI Diffuse optical topography (Near infrared spectroscopy)
|
Boas D
Mandeville JB
Strangman G
|
NIRS agrees well with fMRI, useful in longitudinal studies
|
Neurological Cardiology / Vascular |
| Stroke |
Oxygen consumption Cerebral Blood flow (CBF)
|
Optical imaging |
Boas D
Dunn A
Lo E
|
|
Neurological Cardiology / Vascular |
| Stroke / ischemic |
Cerebral Blood flow (CBF) Relative cerebral blood volume (rCBV) Water EF
|
CAPTIVE MRI |
Bogdanov A
Jenkins B
Kwong K
Weissleder R
|
|
Neurological Cardiology / Vascular |
| Stroke / ischemic |
Vascular occlusion, ischemic brain tissue |
Diffusion / Perfusion weighted imaging MRI CT perfusion CTA
|
Gonzalez R
Harris G
Sorensen AG
Wu O
|
|
Neurological Cardiology / Vascular |
| Stroke / recovery |
Cortical activation during sensorimotor tasks
|
fMRI |
Schaechter J
Rosen BR
|
|
Neurological Cardiology / Vascular |
| Vulnerable plaque |
Atherosclerotic plaque temperature
|
Thermography |
Brady T
Lev M
Waltman A
|
|
Neurological Cardiology / Vascular Inflammatory |
| Vulnerable plaque |
Macrophage content Fibrous cap thickness Plaque Type
|
Optical coherence topography |
Weissleder R |
|
Neurological Cardiology / Vascular Inflammatory |
| Vulnerable plaque |
Subendothelial lipid pool |
Optical coherence topography Near infrared spectroscopy |
Brady T
Muller J
Weissleder R
|
|
Neurological Cardiology / Vascular Inflammatory |
| Vulnerable plaque |
Targeted mircobubble contrast agents |
Contrast enhanced US |
O'Neill MJ
Waltman A
|
|
Neurological Cardiology / Vascular Inflammatory |
| Vulnerable plaque |
Thickness and composition of plaque |
Intravascular US IVUS |
Brady T
Lev M
O'Neill NJ
Waltman A
|
|
Neurological Cardiology / Vascular Inflammatory |
