| Disease / Medical condition |
Biomarker |
Imaging Technique |
Investigators |
Comments |
Disease Category |
Abscess |
Leukocyte accumulation |
SPECT |
Fischman AJ |
Tc-99m HMPAO improvement over Tl-201 and Ga-67 |
Neurological Inflammatory Musculoskeletal Genitourinary Infectious disease Gastrointestinal
|
| AIDS wasting syndrome |
Body fat composition |
CT |
Rosenthal DI |
|
Endocrine Metabolic Musculoskeletal Infectious disease Gastrointestinal
|
| AIDS wasting syndrome / lipodystrophy |
Increased abdominal visceral fat associated with decreased bone mineral density
|
Quantitative CT Dual energy X-ray absorptiometry (DEXA) |
Rosenthal DI |
|
Endocrine Metabolic Musculoskeletal Infectious disease Gastrointestinal |
| Biliary obstruction |
Biliary ductal dilatation |
US CT MRI |
Hahn P
Mueller P
|
|
Gastrointestinal |
| Biliary parasitic disease |
Biliary ductal dilatation |
US CT MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Gastrointestinal Infectious disease |
| Biliary stricture |
MR cholangio-pancreatography |
MRI |
Prasad S
Sahani D
|
|
Gastrointestinal |
| Calculus disease |
MR cholangio- pancreatography |
MRI |
Prasad S
Sahani D
|
|
Endocrine Gastrointestinal |
| Cholangio-carcinoma |
Liver tissue characterization |
MRI |
Hahn PF
Halpern EF
Sahani D
|
Using combined ferrumoxide / Gd-DPTA
|
Oncology / Neoplasm Gastrointestinal |
| Cholangitis |
Ductal dilatation |
MRI |
Prasad S
Sahani D
|
MR cholangio- pancreatography |
Gastrointestinal Infectious disease Inflammatory
|
| Cholecystitis |
Gallstones, Gallbladder wall thickening
|
US CT MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Endocrine Inflammatory Infectious disease Gastrointestinal
|
| Choledo-cholithiasis |
Biliary ductal dialation |
US CT MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Endocrine Inflammatory Gastrointestinal Metabolic |
| Cholelithiasis |
Gallstones |
US CT MRI |
Hahn P
Mueller P
O'Neill MJ
|
|
Endocrine Inflammatory Gastrointestinal Metabolic |
| Cirrhosis |
Caudate lobe enlargement Right posterior hepatic notch
|
MRI CT |
Hahn PF
Sahani D
|
Discrimination of alcohol from virus-induced cirrhosis
|
Gastrointestinal Infectious disease Inflammatory |
| Colorectal carcinoma |
99mTc labeled monoclonal antibody |
SPECT |
Fischman AJ |
Phase III clinical trial with HumaSPECT-Tc
|
Oncology / Neoplasm Gastrointestinal |
| Crohn's disease |
Bowel wall differentiation Inflammation |
MR enteroclysis |
Hahn P |
Use of experimental oral contrast Kaolin, locus bean gum, methylcellulose + Barium
|
Gastrointestinal Inflammatory |
Gastrointestinal bleeding
|
Intraluminal hemorrhage |
SPECT |
Fischman AJ |
|
Gastrointestinal |
| Hepatic cysts |
Liver tissue characterization |
MRI US |
Hahn PF
Harisinghani M
Mueller PR
O'Neill MJ
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Gastrointestinal |
| Hepatic focal nodular hyperplasia |
Liver tissue characterization |
MRI |
Hahn PF
Halpern EF
Sahani D
|
Using combined ferrumoxide / Gd-DPTA
|
Oncology / Neoplasm Gastrointestinal Endocrine |
| Hepatic focal nodular hyperplasia |
Liver tissue characterization |
MRI |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Oncology / Neoplasm Gastrointestinal Endocrine |
| Hepatic hemangioma |
Liver tissue characterization |
MRI US |
Hahn PF
Harisinghani M
Mueller PF
O'Neill MJ
Saini S
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide OR Gd-based chelates
|
Oncology / Neoplasm Gastrointestinal |
| Hepatic neoplasm / primary and secondary |
Glucose metabolism |
PET |
Fischman AJ |
Non-specific marker with wide variety of applications
|
Oncology / Neoplasm Gastrointestinal |
| Hepatic neoplasm / primary and secondary |
Lesion detection |
MRI |
Hahn PF
Harisinghani M
Saini S
Weissleder R
|
Increased SNR and CNR with liver specific contrast agent GD-BOPTA and mangafodipir
|
Oncology / Neoplasm Gastrointestinal |
| Hepatic neoplasm / primary and secondary |
Lesion volume |
US CT MRI |
Harris G
Mueller PR
O’Neill MJ
Saini S
|
Anatomic marker of disease presence |
Oncology / Neoplasm Gastrointestinal |
| Hepatic neoplasm / primary and secondary |
Vascular architecture |
Multidetector CT angiography (MDCTA) |
Hahn PF
Mueller PR
Saini S
Sahani D
|
Presurgical treatment planning |
Oncology / Neoplasm Gastrointestinal |
| Hepatobiliary disorders |
Liver tissue characterization |
MRI |
Hahn P
Harisinghani M
Mueller P
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Gastrointestinal |
| Hepatocellular carcinoma |
Liver tissue characterization |
MRI |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Oncology / Neoplasm Gastrointestinal |
| Hepatocellular carcinoma |
Liver tissue characterization |
MRI |
Hahn PF
Halpern EF
Harisinghani M
Sahani D
|
Using combined ferrumoxide / Gd-DPTA |
Oncology / Neoplasm Gastrointestinal |
| Inflammatory bowl disease (IBD) |
Bowel wall thickening Peri-intestinal inflammation
|
MRI |
Hahn P |
Tissue FISP pulse sequence |
Gastrointestinal Inflammatory |
| Intra-abdominal abscess |
Cyst composition / tissue characterization |
US CT MRI |
Mueller P |
|
Gastrointestinal Genitourinary Infectious disease
|
| Obesity |
Body fat composition |
Quantitative CT MRI US |
Rosenthal DI |
|
Endocrine Metabolic Musculoskeletal Gastrointestinal
|
| Pancreatic adrenal carcinoma |
Degree of circumferential vessel involvement |
Multidetector CT angiography (MDCT) / CTA
|
Boland GW
Mueller PR
Saini S
|
|
Oncology / Neoplasm Gastrointestinal |
| Pancreatic carcinoma |
18 F-fluorodeoxy-glucose |
PET |
Fischman AJ |
|
Oncology / Neoplasm Gastrointestinal
|
| Pancreatic carcinoma |
Vascular involvement Portal Venous invasion |
MRA |
Halpern EF
Saini S
Waltman AC
|
Better predictor than conventional angiography
|
Oncology / Neoplasm Gastrointestinal |
| Pancreatic function |
Acinar cell receptor binding |
MRI |
Brady TJ Shen TT Weissleder R |
Secretin monocrystalline iron oxide nanoparticles (MION)
|
Endocrine Metabolic Gastrointestinal |
| Pancreatic mass |
Contrast enhanced tissue characterization
|
MRI cholangio -pancreatography |
Prasad S
Sahani D
Saini S
|
|
Oncology / Neoplasm Gastrointestinal |
| Pancreatitis |
Chemotactic peptide uptake |
SPECT |
Fischman AJ |
Via 99mTc labeled peptide analog
|
Gastrointestinal Inflammatory Metabolic Infectious disease
|
| Pancreatitis |
Ductal irregularity or obstruction |
MRI |
Prasad S Sahani D |
Visualized by MR cholanio-pancreatography (MRCP)
|
Gastrointestinal Inflammatory Metabolic Infectious disease |
| Portal vein thrombosis |
Intravascular thrombus |
US CT MRI Angiography |
Hahn P
Mueller P
O’Neill MJ
Waltman A
|
|
Cardiology / Vascular Gastrointestinal |
| Rectal carcinoma / advanced staging |
Infiltration of tunica muscularis Presence of positive nodes
|
MRI Multidetector CT angiography (MDCT) US |
Hahn P
Saini S
O'Neill MJ
Mueller P
|
|
Gastrointestinal Oncology / Neoplasm |
| Rectal carcinoma / recurrent |
Peri-rectal fat involvement Spiculated lymph node |
MRI |
Hahn P
Prasad S
Saini S
|
Predictor of high probability of local recurrence
|
Gastrointestinal Oncology / Neoplasm |
| Simple renal cysts |
Cyst composition / tissue characterization Soft tissue inflammation
|
US CT MRI |
Mueller PR |
|
Oncology / Neoplasm Genitourinary Musculoskeletal
|
| Splenic cysts |
Splenic tissue characterization |
MRI |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide
|
Oncology / Neoplasm Gastrointestinal |
| Splenic neoplasm |
Splenic tissue characterization |
MRI |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide
|
Oncology / Neoplasm Gastrointestinal |
| Splenic trauma |
Splenic tissue characterization |
MRI |
Harisinghani M
Weissleder R
|
Using ultrasmall superpara-magnetic iron oxide
|
Gastrointestinal Cardiology / Vascular |
