| Disease / Medical Condition |
Biomarker |
Imaging technique |
Investigators |
Comments |
Disease Category |
Abscess |
Leukocyte accumulation |
SPECT |
Fischman AJ |
Tc-99m HMPAO improvement over Tl-201 and Ga-67 |
Neurological
Inflammatory
Musculoskeletal
Genitourinary
Infectious disease
Gastrointestinal
|
| Abscess |
Restricted diffusion |
Diffusion weighted imaging (DWI) |
Grant E
Gonzalez RG
Schaefer P
|
|
Neurological Inflammatory Infectious disease |
| Allergic drug reaction |
Increased pulmonary interstitial markings |
CT |
McLoud TC
Shepard J
|
|
Endocrine Metabolic Inflammatory |
| Amyloid arthropathy / crystaline disease |
Periarticular erosion |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory Metabolic |
| Arthritis |
Joint space narrowing |
Plain radiographs |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / inflammatory |
Articular cartilage thickness |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / inflammatory |
Increased synovial glucose metabolism |
PET |
Fischman AJ
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / inflammatory |
Periarticular erosion |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / inflammatory |
Synovial thickening |
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / rheumatoid |
Articular cartilage thickness |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal Inflammatory |
| Arthritis / septic |
Cyst composition / tissue characterization |
PET |
Palmer W
Rosenthal DI
|
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Arthritis / septic |
Increased synovial glucose metabolism |
MRI |
Palmer W
Rosenthal DI |
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Arthritis / septic |
Periarticular erosion |
Plain radiographs MRI |
Palmer W
Rosenthal DI |
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Arthritis / septic |
Synovial thickening |
Plain radiographs MRI |
Palmer W
Rosenthal DI |
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Cholangitis |
Biliary ductal dilatation |
MRI |
Prasad S
Sahani D |
MR cholangio-pancreatography |
Gastrointestinal
Infectious disease
Inflammatory
|
| Cholecystitis |
Gallstones Gallbladder wall thickening |
US
CT
MRI |
Hahn P
Mueller P |
|
Endocrine
Inflammatory
Infectious disease
Gastrointestinal
|
| Choledo-cholithiasis |
Biliary ductal dilatation |
US
CT
MRI |
Hahn P
Mueller P |
|
Endocrine
Inflammatory
Gastrointestinal
Metabolic
|
| Cholelithiasis |
Gallstones |
US
CT
MRI |
Hahn P
Mueller P
O'Neill MJ |
|
Endocrine
Inflammatory
Gastrointestinal
Metabolic
|
| Cirrhosis |
Caudate lobe enlargement Right Posterior Hepatic notch |
MRI
CT |
Hahn PF
Sahani D |
Discrimination of alcohol from virus-induced cirrhosis |
Gastrointestinal
Infectious disease
Inflammatory
|
| Connective tissue disorders |
Increased pulmonary interstitial markings
|
CT |
McLoud TC
Shepard J
|
|
Inflammatory |
| Crohn's disease |
Bowel wall differentiation Inflammation |
MR enteroclysis |
Hahn P |
Use of experimental oral contrast Kaolin, locus bean gum, methylcellulose + Barium
|
Gastrointestinal Inflammatory |
| Encephalitis / west nile virus |
Thalamus and substantia nigra hyperintensity |
MRI |
Gonzalez RG Sorensen AG |
Disease confirmation and progression monitoring
|
Neurological
Infectious disease
Inflammatory
|
| Ganglion cyst |
Cyst composition / tissue characterization |
US
CT
MRI
|
Rosenthal DI |
|
Musculoskeletal
Inflammatory
|
Inflammatory abdominal aortic aneurysm (IAAA)
|
Perianeurysmal fibrosis Aneurysmal wall thickness |
CT |
Brady T
Saini S
Waltman A
|
|
Inflammatory
Cardiology / Vascular |
| Inflammatory bowl disease (IBD) |
Bowel wall thickening Peri-intestinal inflammation |
MRI |
Hahn P |
Tissue FISP pulse sequence |
Gastrointestinal
Inflammatory
|
| Interstitial pulmonary edema |
Increased pulmonary interstitial markings |
CT |
McLoud TC Shepard J |
|
Inflammatory
Cardiology / Vascular
Infectious disease
|
| Lymphangio-carcinomatosis |
Increased pulmonary interstitial markings
|
CT |
McLoud TC Shepard J |
|
Inflammatory
Oncology / Neoplasm |
| Lymphatic extension of pelvic malignancy (gynecological oncology) |
Abnormal lymphatic uptake of tracer |
MRI |
Hahn PF
Harisinghani M
Mueller PR
Saini S
Weissleder R
|
MR Lymphangio-graphy using ultrasmall superpara-magnetic iron oxide
|
Oncology / Neoplasm
Inflammatory |
| Multiple sclerosis |
Choline / Sodium (NA) ratio Creatine / Sodium (NA) ratio
|
MRS |
Jenkins B
Gonzalez RG
|
|
Neurological Inflammatory |
| Multiple sclerosis |
Comparative brainstem analysis MS plaque demylination |
MRI |
Jenkins B
Rosen BR
Stufflebeam SM
|
|
Neurological Inflammatory |
| Multiple sclerosis |
Decreased N-acetylaspartate (NAA) |
MRS |
Jenkins B
Gonzalez RG
|
|
Neurological Inflammatory |
| Multiple sclerosis |
Thalamic neuronal loss |
MRI
fMRI
MRS |
Gonzalez RG
Fischl B
Kuperberg G
|
|
Neurological Inflammatory |
| Multiple sclerosis |
Tissue characterization Cortical thickness
|
fMRI
MRI
morphometry
|
Fischl B
Kuperberg G |
|
Neurological Inflammatory |
| Myocarditis |
Myocardial function contractility Perfusion / diffusion |
MRI |
Brady T |
|
Cardiology / Vascular
Inflammatory
Infectious disease
Endocrine Metabolic
|
| Myocarditis |
Myocardial function contractility Perfusion / diffusion |
Nuclear medicine |
Fischman A |
|
Cardiology / Vascular
Inflammatory
Infectious disease
Endocrine Metabolic
|
| Myopathy |
Soft tissue inflammation |
MRI |
Palmer W
Rosenthal DI
|
|
Endocrine
Inflammatory
Infectious disease
Cardiology / Vascular
|
| Osteoarthritis |
Articular cartilage thickness |
Plain radiographs MRI |
Palmer W
Rosenthal DI
|
|
Musculoskeletal
Inflammatory
|
| Osteoarthritis |
Cartilage thickness Fibrillations Fibrosis |
Intra-articular Optical coherence topography
|
Palmer WE |
|
Musculoskeletal Inflammatory |
| Osteoarthritis |
Osteoblastic activity |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal Inflammatory
|
| Pancreatitis |
Chemotactic peptide uptake |
SPECT |
Fischman AJ |
Via 99mTc labeled peptide analog |
Gastrointestinal
Inflammatory
Infectious disease
Endocrine Metabolic
|
| Pancreatitis |
Ductal irregularity or obstruction |
MRI |
Prasad S
Sahani D
Saini S |
Visualized by MR Cholanio-pancreatography |
Gastrointestinal
Inflammatory
Infectious disease
Endocrine Metabolic
|
| Pigmented villonodular synovitis |
Increased synovial glucose metabolism |
PET |
Fischman AJ
Palmer W
Rosenthal DI
|
|
Inflammatory Musculoskeletal |
| Pigmented villonodular synovitis |
Periarticular erosion |
Plain radiographs
MRI |
Palmer W
Rosenthal DI
|
|
Inflammatory Musculoskeletal |
| Pigmented villonodular synovitis |
Synovial thickening |
MRI |
Palmer W
Rosenthal DI
|
|
Inflammatory Musculoskeletal
|
| Pneumonitis |
Pulmonary consolidation |
CT MRI |
McLoud TC
Shepard J
|
|
Infectious disease Inflammatory |
| Soft tissue infection |
Leukocyte accumulation |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal
Inflammatory
Infectious disease
|
| Soft tissue infection |
Osteoblastic activity |
Nuclear medicine |
Fischman AJ |
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Soft tissue infection |
Soft tissue inflammation |
MRI |
Rosenthal D
Palmer W
|
|
Infectious disease
Musculoskeletal
Inflammatory
|
| Trauma |
Edema / change in signal intensity and apparent diffusion constant
|
MRI Diffusion weighted imaging |
Palmer W
Rosenthal DI
|
|
Musculoskeletal
Inflammatory
|
| Trauma |
Soft tissue inflammation |
MRI |
Palmer W Rosenthal DI |
|
Musculoskeletal
Inflammatory
|
| Trauma |
Soft tissue inflammation |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal
Inflammatory
|
| Trauma |
Soft tissue uptake of radiotracers |
Nuclear medicine |
Fischman AJ |
|
Musculoskeletal Inflammatory
|
| Vulnerable plaque |
Atherosclerotic plaque temperature |
Thermography |
Brady T
Lev M
Waltman A
|
|
Neurological
Cardiology / Vascular Inflammatory
|
| Vulnerable plaque |
Macrophage content Fibrous cap thickness Plaque Type
|
Optical coherence tomography (OCT) |
Weissleder R |
|
Neurological Cardiology / Vascular Inflammatory |
| Vulnerable plaque |
Subendothelial lipid pool |
Optical coherence tomography (OCT) Near infrared spectroscopy (NIRS)
|
Brady T
Muller J
Weissleder R
|
|
Neurological
Cardiology / Vascular Inflammatory
|
| Vulnerable plaque |
Targeted mircobubble contrast agents |
Contrast enhanced US |
O'Neill MJ
Waltman A
|
|
Neurological Cardiology / Vascular Inflammatory
|
| Vulnerable plaque |
Thickness and composition of plaque |
Intravascular US IVUS |
Brady T
Lev M
O'Neill MJ
Waltman A
|
|
Neurological Cardiology / Vascular Inflammatory |
