| Investigators |
Disease / Medical condition |
Biomarker |
Imaging Technique |
Comments |
Disease Category |
Alpert N
Choi N
Fischman A
|
Head and neck neoplasm / primary and secondary |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications |
Neurological Oncology / Neoplasm |
Alpert N
Choi N
Fischman A
Kennedy
Rosen B
|
CNS neoplasm / primary and secondary, presence and viability |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications |
Neurological Oncology / Neoplasm |
Alpert N
Fischman A
Rauch SL
|
Anorexia |
Relative cerebral blood flow (rCBF) |
PET |
|
Neurological |
Alpert N
Fischman A
Heckers S
Rauch SL
Schaefer P
|
Schizophrenia |
Cerebral blood flow (CBF) |
PET |
Regional activation during cognitive paradigms |
Neurological |
Alpert N
Fischman A
Heckers S
Rauch SL
Schaefer P
|
Schizophrenia |
Neural activation of dorsolateral pre-frontal cortex, hippocampus and cerebellum |
PET |
Regional activation during cognitive paradigms |
Neurological |
Alpert NM
Fischman AJ
|
Renal disease |
Decreased regional blood flow |
PET |
|
Metabolic Endocrine |
Alpert NM
Fischman AJ
|
Renal disease |
Hippuran clearance |
PET |
|
Metabolic Endocrine |
Alpert NM
Choi NC
Fischman AJ
|
Breast neoplasm |
Glucose metabolism |
PET |
|
Oncology / Neoplasm |
Alpert NM
Fischman AJ
|
Skeletal muscle injury and repair |
Musculoskeletal blood flow |
PET |
Animal study Use of H2(15)O to study muscle metabolism |
Musculoskeletal |
Belliveau
Kennedy D
Rosen BR
|
CNS neoplasm / primary and secondary |
Microvascular blood volume and microvascular density |
fMRI
MRI |
|
Neurological Oncology / Neoplasm |
Belliveau
Kwong K
Rosen BR
|
Brain function |
Cerebral blood flow (CBF ) |
MRI
fMRI
PET |
Response to stimuli |
Neurological Metabolic |
Bencardino JT
Palmer WE
|
SLAP lesions of the shoulder |
Articular labrum fraying |
MR arthrography |
|
Musculoskeletal |
Bencardino JT
Palmer WE
|
SLAP lesions of the shoulder |
Bicep anchor avulsion |
MR arthrography |
|
Musculoskeletal |
Boas D
Dunn A
|
CNS neoplasm / primary and secondary, presence and viability
|
Oxygen consumption |
Optical |
Diffuse Optical imagine (DOI) |
Neurological Oncology / Neoplasm |
Boas D
Dunn A |
CNS neoplasm / primary and secondary, presence and viability |
Cerebral blood flow (CBF) |
Optical |
Diffuse optical imagine (DOI) |
Neurological Oncology / Neoplasm |
Boas D
Dunn A
|
Brain development |
Oxygen consumption |
Optical Imaging |
Diffuse optical imaging (DOI) |
Neurological Metabolic |
Boas D
Dunn A
|
Brain development |
Cerebral blood flow (CBF) |
Optical Imaging |
Diffuse optical imaging (DOI) |
Neurological Metabolic |
Boas D
Dunn A
|
Alzheimer's disease |
Oxygen utilization |
Optical |
Combining of multi-wavelength and laser speckle contrast imaging
|
Neurological Metabolic |
Boas D
Dunn A
|
Alzheimer's disease |
Cerebral blood flow (CBF) |
Optical |
Combining of multi-wavelength and laser speckle contrast imaging
|
Neurological Metabolic |
Boas D
Mandeville JB
Strangman G
|
Stroke |
Neuronal activation |
fMRI Diffuse optical topography (Near infrared spectroscopy) |
NIRS agrees well with fMRI, useful in longitudinal studies |
Neurological Cardiology / Vascular |
Boas D
Mandeville JB
Strangman G
|
Stroke |
CMRO2 |
fMRI Diffuse optical topography (Near infrared spectroscopy) |
NIRS agrees well with fMRI, useful in longitudinal studies |
Neurological Cardiology / Vascular |
Boas D
Dunn A
|
Migraine |
Restricted diffusion |
Optical |
|
Neurological |
Boas D
Bolay
Dunn A
|
Migraine |
Cerebral blood flow (CBF) |
Laser speckle contrast imaging Diffuse optical topography |
|
Neurological |
Boas D
Dunn A
Lo E
|
Stroke |
Oxygen consumption |
Optical imaging |
|
Neurological Cardiology / Vascular |
Boas D
Dunn A
Lo E
|
Stroke |
Cerebral Blood flow (CBF) |
Optical imaging |
|
Neurological Cardiology / Vascular |
Bogdanov A
Kwong K
Weissleder R
|
Neoplasm / primary and secondary |
Tumor growth rate |
MRI
SPECT Dual tracer NMR |
SPECT via uptake of long-circulating dextrin coated iron oxide (LCDIO) Rodent model
|
Oncology / Neoplasm |
Bogdanov A
Mahmood U
Weissleder R
|
Neoplasm / primary and secondary |
Tumoral proteinase |
Optical Near infrared spectroscopy |
Rodent model |
Oncology / Neoplasm |
Bogdanov A
Weissleder R
|
Neoplasm / primary and secondary |
Tumor angiogenesis Macromolecular contrast extravasate |
MRI SPECT |
Animal model using pegylated DOTA derivatized graft copolymers
|
Oncology / Neoplasm |
Bogdanov A
Bremer C
Rosen BR
Weissleder R
|
Neoplasm / primary and secondary |
Tumor angiogenesis |
MRI Dynamic susceptibility contrast (DSC) / monocrystalline iron oxide nanoparticles (MION)
|
High resolution MR using long circulating iron oxide contrast agents Rodent model |
Oncology / Neoplasm |
Bogdanov A
Weissleder R |
CNS neoplasm / primary and secondary |
Tumor growth rate |
MRI |
Serial studies of tumor volume using uptake of long-circulating dextrin coated iron oxide (LCDIO) Rodent model
|
Neurological Oncology / Neoplasm |
Bogdanov A
Jenkins B
Kwong K
Weissleder R
|
Stroke / ischemic |
Cerebral blood flow (CBF) |
CAPTIVE MRI |
|
Neurological Cardiology / Vascular |
Bogdanov A
Jenkins B
Kwong K
Weissleder R
|
Stroke / ischemic |
Relative cerebral blood volume (rCBV) |
CAPTIVE MRI |
|
Neurological Cardiology / Vascular |
Bogdanov A
Jenkins B
Kwong K
Weissleder R
|
Stroke / ischemic |
Water EF |
CAPTIVE MRI |
|
Neurological Cardiology / Vascular |
Bogdanov M
Chen YC
Jenkins B
Rosen B
|
Brain function / mapping - dopaminergic neurotransmitter activity
|
Relative cerebral blood flow (rCBF) |
Pharmacologic
MRI
PET
fMRI |
Using D-amphetamine and CFT |
Neurological Metabolic |
Bogdanov M
Chen YC
Jenkins B
Rosen B
|
Brain function / mapping - dopaminergic neurotransmitter activity
|
Relative cerebral blood volume (rCBV) |
Pharmacologic
MRI
PET
fMRI |
Using D-amphetamine and CFT |
Neurological Metabolic |
Boland GW
Hahn PF
Mueller PR
|
Adrenal neoplasm |
Relative % contrast washout |
CT |
Differential diagnosis of adrenal masses |
Oncology / Neoplasm Genitourinary |
Boland GW
Mueller PR
Saini S
|
Pancreatic adrenal carcinoma |
Degree of circumferential vessel involvement |
Multidetector CT angiography (MDCT) / CTA
|
|
Oncology / Neoplasm Gastrointestinal |
| Brady T |
Acute myocardial infarction
|
Intravascular thrombus |
MRI |
|
Cardiology / Vascular |
| Brady T |
Atherosclerosis / central |
Arterial calcification |
CT |
|
Cardiology / Vascular Metabolic
|
| Brady T |
Arteriosclerosis / peripheral |
Arterial calcification |
CT |
|
Cardiology / Vascular Metabolic
|
| Brady T |
Coronary artery disease |
Arterial calcification |
CT |
|
Cardiology / Vascular Metabolic
|
| Brady T |
Myocarditis |
Myocardial function contractility |
MRI |
|
Cardiology / Vascular Inflammatory Infectious disease Endocrine Metabolic
|
| Brady T |
Myocarditis |
Perfusion / diffusion |
MRI |
|
Cardiology / Vascular Inflammatory Infectious disease Endocrine Metabolic
|
Brady T
Fischman A
|
Coronary artery disease |
Myocardial contractility / function |
MRI
Nuclear Medicine |
|
Cardiology / Vascular Metabolic |
Brady T
Lev M
O'Neill NJ
Waltman A
|
Vulnerable plaque |
Thickness and composition of plaque |
Intravascular
US IVUS |
|
Neurological Cardiology / Vascular Inflammatory |
Brady T
Lev M
Waltman A
|
Vulnerable plaque |
Atherosclerotic plaque temperature |
Thermography |
|
Neurological Cardiology/ Vascular Inflammatory |
Brady T
Saini S
Waltman A
|
Inflammatory abdominal aortic aneurysm (IAAA)
|
Perianeurysmal fibrosis |
CT |
|
Inflammatory Cardiology / Vascular |
Brady T
Saini S
Waltman A |
Inflammatory abdominal aortic aneurysm (IAAA)
|
Aneurysmal wall thickness |
CT |
|
Inflammatory Cardiology / Vascular |
Brady T
Muller J |
Vulnerable plaque |
Subendothelial lipid pool |
Optical coherence topography Near infrared spectroscopy |
|
Neurological Cardiology / Vascular |
Brady TJ
Shen TT
Weissleder R
|
Pancreatic function |
Acinar cell receptor binding |
MRI |
Secretin monocrystalline iron oxide nanoparticles (MION)
|
Endocrine Metabolic Gastrointestinal |
Bremer C
Bogdanov A
Weissleder R
|
Breast neoplasm |
Tumor associated enzymatic activity |
Optical Near infrared spectroscopy |
Expression levels of cathepsin-B activity in animal models of breast cancer
|
Oncology / Neoplasm |
Bush G
Fischman A
Rosen B
|
Attention deficit hyperactivity disorder (ADHD) |
ACCD activation (anterior cingulate cortex division) |
fMRI
PET |
|
Neurological |
Caviness VS
Dale A
Fischl B
Kennedy D
|
Brain development / -anencephaly -microcephaly -holoprosencephaly
|
Cortical thickness, volume and location |
MRI morphometry fMRI |
|
Neurological |
Caviness VS
Kennedy D
|
Brain injury / toxicity and trauma |
Focal atrophy |
MRI |
|
Neurological |
Caviness VS
Harris G
Kennedy D
|
Autism |
Frontal language area |
MRI |
Reversal of morphometric asymmetry in frontal language area
|
Neurological |
Caviness VS
Gonzalez RG
Schaefer P
Sorensen AG
|
Stroke |
Intravascular thrombus |
CT / CTA MRI / MRA Angiography |
|
Neurological Cardiology / Vascular |
| Cheng LL Gonzalez RG |
Prostate cancer |
Spermine levels |
MRS magic angle spinning |
Proposed endogenous inhibitor of prostate CA growth
|
Oncology / Neoplasm Genitourinary |
Choi NC
Fischman AJ
Weissleder R |
Lung neoplasm / non small cell carcinoma |
Glucose metabolism |
PET |
Pilot trial in NSCLC showed good inverse correlation between MR post radiation and outcomes
|
Oncology / Neoplasm |
Dale A
Hyman B
Fischl B
Kennedy D |
Alzheimer's disease |
Hippocampal size |
MRI Quantitative volumetric morphometry |
Accurately indicates absence of disease progression in therapeutic trials - allows markedly reduced subject numbers
|
Neurological Metabolic |
Dale A
Grant E
Mandeville J
Rosen B
Stufflebeam SM
Wald LL
|
Epilepsy |
Cortical dysplasia |
MRI / MEG fMRI |
|
Neurological |
Dale A
Fischl B
Harris G
Kennedy D
Rosas D
|
Huntington's disease |
Cortical thickness |
fMRI
MRI
morphometry |
|
Neurological |
Davis T
Rosen B
Wald LL
Weissleder R
|
CNS neoplasm / primary and secondary |
Tumor angiogenesis |
MRI
MRS
MRA
|
Measured by dynamic susceptibility contrast (DSC) and monocrystalline iron oxide nanoparticles (MION)
|
Neurological Oncology / Neoplasm |
Davis T
Rosen B
Wald LL
Weissleder R
|
Glioma |
Tumor angiogenesis |
MRI
MRS
MRA
|
Measured by dynamic susceptibility contrast (DSC) and monocrystalline iron oxide nanoparticles (MION)
|
Neurological Oncology / Neoplasm |
| Feld MS (MIT) |
Breast neoplasm |
Microcalcifications |
Raman Spectroscopy |
Differential diagnosis of benign from malignant microcalcifications
|
Oncology / Neoplasm |
Fischl B
Harris G
Kennedy D
Kuperberg G
|
Schizophrenia |
Cortical thickness |
MRI (morphometry) |
|
Neurological |
Fischl B
Kuperberg G
|
Multiple sclerosis |
Tissue characterization |
fMRI
MRI
morphometry
|
|
Neurological Inflammatory |
Fischl B
Kuperberg G
|
Multiple sclerosis |
Cortical thickness |
fMRI
MRI
morphometry
|
|
Neurological Inflammatory |
| Fischman A |
Coronary artery disease |
Myocardial blood flow via 13N-ammonia
|
Nuclear medicine SPECT |
|
Cardiology / Vascular Metabolic |
| Fischman A |
Coronary artery disease |
Myocardial perfusion |
Nuclear medicine |
|
Cardiology / Vascular Metabolic
|
| Fischman A |
Dyskinesia (PNKD) |
Dopa decarboxylase activity
|
PET |
|
Neurological Musculoskeletal |
| Fischman A |
Ischemic heart disease |
Myocardial blood flow via 13N-ammonia
|
Nuclear medicine SPECT |
|
Cardiology / Vascular |
| Fischman A |
Myocarditis |
Perfusion / diffusion |
Nuclear medicine |
|
Cardiology / Vascular Inflammatory Infectious disease Endocrine Metabolic
|
| Fischman A |
Myocarditis |
Myocardial function contractility |
Nuclear medicine |
|
Cardiology / Vascular Inflammatory Infectious disease Endocrine Metabolic
|
| Fischman A |
Osseous neoplasm / primary and secondary |
Osteoblastic activity |
Nuclear medicine |
|
Oncology / Neoplasm Musculoskeletal
|
| Fischman A |
Pulmonary embolism |
Ventilation / perfusion mismatch |
Nuclear medicine |
|
Cardiology / Vascular |
| Fischman A |
CNS AIDS / fungal and opportunistic infections
|
Focal brain uptake |
PET SPECT |
|
Neurological |
Fischman A
Kennedy D
Rosen B
|
Glioma |
Glucose uptake |
PET |
|
Neurological Oncology / Neoplasm |
Fischman A
Rauch SL |
Attention deficit hyperactivity disorder (ADHD)
|
Dopamine transporter density |
SPECT |
|
Neurological |
Fischman A
Weissleder R
|
Alzheimer's disease |
Directed molecular probes |
PET
SPECT Optical |
Animal modeling Optical with exogenous contrast agents
|
Neurological Metabolic |
Fischman A
Halgren E
Rosen B
Sorensen AG
Stuffelbeam SM
|
Pain |
Cortical activity |
fMRI
PET
SPECT
MEG |
|
Neurological Musculoskeletal |
Fischman A
Rauch SL
Rosen BR
|
Obsessive compulsive disorder |
Cortical activation during provoked conditions |
fMRI
PET
SPECT |
|
Neurological |
Fischman A
Weissleder R
|
Huntington's disease |
Directed molecular probes |
MRI
PET Optical |
|
Neurological |
Fischman A
Halpern E
Sahani D
|
Parkinson’s disease |
Dopamine transporter (DAT) density |
SPECT (using I-123 altropane) |
|
Neurological |
Fischman A
Halpern E
Sahani D
|
Parkinson’s disease |
Dopamine binding potential |
SPECT (using I-123 altropane) |
|
Neurological |
| Fischman AJ |
Abscess |
Leukocyte accumulation |
SPECT |
Tc-99m HMPAO improvement over Tl-201 and Ga-67 |
Neurological Inflammatory Musculoskeletal Genitourinary Infectious disease Gastrointestinal
|
| Fischman AJ |
Bone fracture / healing |
Osteoblastic activity |
Nuclear medicine |
|
Musculoskeletal Metabolic
|
| Fischman AJ |
Colorectal carcinoma |
99mTc labeled monoclonal antibody |
SPECT |
Phase III clinical trial with HumaSPECT-Tc
|
Oncology / Neoplasm Gastrointestinal |
| Fischman AJ |
Gastrointestinal bleeding
|
Intraluminal hemorrhage |
SPECT |
|
Gastrointestinal |
| Fischman AJ |
Hepatic neoplasm / primary and secondary |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications
|
Oncology / Neoplasm Gastrointestinal |
| Fischman AJ |
Neoplasm / primary and secondary |
Local uptake of specific tumor avid radiotracers
|
Nuclear medicine |
|
Musculoskeletal Oncology / Neoplasm |
| Fischman AJ |
Osseous neoplasm / primary and secondary
|
Glucose metabolism |
PET |
|
Oncology / Neoplasm Musculoskeletal |
| Fischman AJ |
Osteoarthritis |
Osteoblastic activity |
Nuclear medicine |
|
Musculoskeletal Inflammatory
|
| Fischman AJ |
Osteomyelitis |
Leukocyte accumulation |
Nuclear medicine |
Radiolabled IL-8 accumulation |
Infectious disease Musculoskeletal
|
| Fischman AJ |
Osteomyelytis |
Osteoblastic activity |
Nuclear medicine |
Uptake of bone-seeking radio-pharmaceuticals
|
Musculoskeletal Infectious disease
|
| Fischman AJ |
Ovarian neoplasm / presence and viability |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications
|
Oncology / Neoplasm Genitourinary |
| Fischman AJ |
Pancreatic carcinoma |
18 F-fluorodeoxy-glucose |
PET |
|
Oncology / Neoplasm Gastrointestinal
|
| Fischman AJ |
Pancreatitis |
Chemotactic peptide uptake |
SPECT |
Via 99mTc labeled peptide analog |
Gastrointestinal Inflammatory Metabolic Infectious disease Endocrine
|
| Fischman AJ |
Pulmonary neoplasm / presence and viability |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications
|
Oncology / Neoplasm |
| Fischman AJ |
Renal neoplasm / primary and secondary |
Glucose metabolism |
PET |
|
Oncology / Neoplasm Genitourinary
|
| Fischman AJ |
Soft tissue infection |
Leukocyte accumulation |
Nuclear medicine |
|
Infectious disease Musculoskeletal Inflammatory
|
| Fischman AJ |
Soft tissue infection |
Osteoblastic activity |
Nuclear medicine |
|
Infectious disease Musculoskeletal Inflammatory
|
| Fischman AJ |
Soft tissue neoplasm / primary and secondary |
Glucose metabolism |
PET |
Non-specific marker with wide variety of applications
|
Oncology / Neoplasm Musculoskeletal |
| Fischman AJ |
Trauma |
Soft tissue inflammation |
Nuclear medicine |
|
Musculoskeletal Inflammatory
|
| Fischman AJ |
Trauma |
Soft tissue uptake of radiotracers |
Nuclear medicine |
|
Musculoskeletal Inflammatory
|
| Fischman AJ Jenkins B |
Neoplasm / primary and secondary |
Pharmacokinetics Biodistribution Non-tumor uptake |
SPECT
PET MRS |
Additional use for determining in vivo heterogeneity of tumor uptake
|
Oncology / Neoplasm |
Fischman AJ
Hunter GJ
Weissleder R
|
Neoplasm / primary and secondary |
Directed molecular probes |
MRI
PET Optical |
|
Oncology / Neoplasm |
Fischman AJ
McLoud TC
Weissleder R
|
Lung neoplasm / primary and secondary |
Mediastinal nodal status |
PET
MRI
CT |
Physiologic imaging with FDG or iron oxide particles in NSCLC
|
Oncology / Neoplasm |
Fischman AJ
Palmer W
Rosenthal DI
|
Soft tissue infection |
Soft tissue inflammation |
MRI
Nuclear medicine |
|
Infectious disease Musculoskeletal Inflammatory |
Fischman AJ
Palmer W
Rosenthal DI
|
Pigmented villonodular synovitis |
Increased synovial glucose metabolism |
PET |
|
Inflammatory Musculoskeletal |
Fischman AJ
Palmer W
Rosenthal DI
|
Arthritis / inflammatory |
Increased synovial glucose metabolism |
PET |
|
Musculoskeletal Inflammatory |
Fischman AJ
Palmer WE
Rosenthal DI
|
Neoplasm / primary and secondary |
Soft tissue inflammation |
Nuclear medicine
MRI |
|
Oncology / Neoplasm |
Fischman AJ
McLoud TC
|
Pulmonary neoplasm |
Permeability surface area product |
PET
MRI |
|
Oncology / Neoplasm |
Fishman A
Livni E
Rosen B
|
Parkinson’s disease |
Dopaminergic neurotransmitter activity |
fMRI
PET |
Pet using 11C-CRT |
Neurological |
Gonzales RG
Jenkins BG
|
Parkinson’s disease |
N-acetylaspartate (NAA) levels over time
|
MRS |
|
Neurological |
Gonzalez R
Lev MH
Waltman A
|
Intracranial arterial dissection |
Anatomic disruption of arterial wall |
CTA
MRA Angiography |
|
Neurological Cardiology / Vascular |
Gonzalez R
Lev MH
Schaefer P
Schwamm
Sorensen AG
|
Head and neck neoplasm / primary and secondary |
Lesion volume |
CT
MRI |
Anatomic marker of disease presence |
Neurological Oncology / Neoplasm |
Gonzalez R
Hunter G
Lev M
Waltman A
|
Arteriosclerosis / peripheral |
Lumen vascular diameter |
CTA
MRA
Angiography |
|
Cardiology / Vascular Metabolic |
Gonzalez R
Harris G
Kennedy D
Lev
Schaefer P
Sorensen AG
|
CNS neoplasm / primary and secondary |
Lesion volume |
CT
MRI
morphometry |
Anatomic marker of disease presence Response to therapy |
Neurological Oncology / Neoplasm |
Gonzalez R
Harris G
Sorensen AG
|
Stroke / ischemic |
Vascular occlusion |
Diffusion / perfusion weighted imaging MRI CT perfusion CTA
|
|
Neurological Cardiology / Vascular |
Gonzalez R
Harris G
Sorensen AG
|
Stroke / ischemic |
Ischemic brain tissue |
Diffusion / perfusion weighted imaging MRI CT perfusion CTA
|
|
Neurological Cardiology / Vascular |
Gonzalez R
Husiman TA
Sorensen AG
|
CNS neoplasm / primary and secondary |
N-acetylaspartate (NAA) |
MRS |
Metabolism, tumor viability and response to therapy
|
Neurological Oncology / Neoplasm |
Gonzalez R
Husiman TA
Sorensen AG
|
CNS neoplasm / primary and secondary |
Choline |
MRS |
Metabolism, tumor viability and response to therapy
|
Neurological Oncology / Neoplasm |
Gonzalez R
Husiman TA
Sorensen AG
|
CNS neoplasm / primary and secondary |
Lactate |
MRS |
Metabolism, tumor viability and response to therapy
|
Neurological Oncology / Neoplasm |
Gonzalez R
Husiman TA
Sorensen AG
|
CNS neoplasm / primary and secondary |
Phosphocreatine |
MRS |
Metabolism, tumor viability and response to therapy |
Neurological Oncology / Neoplasm |
Gonzalez R
Schaefer P
Schwamm LH
|
CNS AIDS / neuroinflammation neurodegeneration
|
N-acetylaspartate (NAA) |
MRS |
|
Neurological |
Gonzalez R
Schaefer P
Schwamm LH
|
CNS AIDS / neuroinflammation neurodegeneration
|
Choline |
MRS |
|
Neurological |
Gonzalez R
Schaefer P
Schwamm LH
|
CNS AIDS / neuroinflammation neurodegeneration |
Myoinositol (MI) |
MRS |
|
Neurological |
Gonzalez R
Hunter G
Lev M
Waltman A
|
Arteriosclerosis / central |
Vascular lumen diameter |
CTA
MRA
Angiography |
|
Metabolic Cardiology / Vascular |
Gonzalez R
Waltman A
|
Carotid dissection |
Anatomic disruption of arterial wall |
US CT / CTA MRI / MRA Angiography
|
|
Neurological Cardiology / Vascular |
Gonzalez R
Waltman A
|
Aortic dissection |
Anatomic disruption of arterial wall |
US
CT
MRI
Angiography
|
|
Cardiology / Vascular |
| Gonzalez RG |
Cerebral malaria |
Diffuse cerebral edema with thalamic +/- cerebellar hypo-attenuation
|
CT |
|
Neurological Infectious disease |
| Gonzalez RG |
Infectious disease / cerebral malaria |
Diffuse cerebral edema with thalamic +/- cerebellar hypo-attenuation
|
CT |
|
Neurological Infectious disease |
| Gonzalez RG |
Alzheimer's disease |
Neuronal injury
|
MRI |
|
Neurological Metabolic |
Gonzalez RG
Hunter G |
HIV |
Increased Cerebral blood volume (CBV) |
fMRI |
Cerebral injury related to HIV infection
|
Infectious disease |
Gonzalez RG
Kwong KK
Sorensen AG
Weissleder R
|
Glioma |
Blood-tumor barrier permeability (BTP) |
MRI
fMRI |
|
Neurological Oncology / Neoplasm |
Gonzalez RG
Sorensen AG
|
Encephalitis / west nile virus |
Thalamus and substantia nigra hyperintensities |
MRI |
Disease confirmation and progression monitoring
|
Neurological Infectious disease Inflammatory |
Gonzalez RG
Sorensen AG
Rosen B
|
Glioma |
Cerebral blood volume (CBV) |
MRI
fMRI |
|
Neurological Oncology / Neoplasm |
Gonzalez RG
Sorensen AG
Rosen B
|
Glioma |
Cerebral blood flow (CBF) |
MRI
fMRI |
|
Neurological Oncology / Neoplasm |
Gonzalez RG
Grant E
|
Asphyxia |
Altered vascular and tissue permeability |
CT |
|
Neurological |
Gonzalez RG
Jenkins B
Rosen B
|
Brain function / neuronal content |
N-acetylaspartate (NAA) Images |
MRI chemical shift Echo-planar imaging (EPI)
|
|
Neurological Metabolic |
Gonzalez RG
Jenkins B
|
Alzheimer's disease |
Myoinositol |
MRS |
|
Neurological Metabolic |
Gonzalez RG
Jenkins B
|
Alzheimer's disease |
N-acetylaspartate (NAA) |
MRS |
|
Neurological Metabolic |
Gonzalez RG
Fischl B
Kuperberg G
|
Multiple sclerosis |
Thalamic neuronal loss |
MRI fMRI MRS |
|
Neurological Inflammatory |
Grant E
Schaefer P
Sorensen AG
Rosen BR
|
Migraine |
Cerebral blood flow (CBF) |
Diffusion / perfusion weighted imaging fMRI |
|
Neurological |
Grant E
Schaefer P
Sorensen AG
Rosen BR
|
Migraine |
Cerebral blood volume (CBV) |
Diffusion / perfusion weighted imaging fMRI |
|
Neurological |
Grant E
Schaefer P
Sorensen AG
Rosen BR
|
Migraine |
Mean transit time (MTT) |
Diffusion / perfusion weighted imaging fMRI |
|
Neurological |
Grant E
Gonzalez RG
Schaefer P
|
Abscess |
Restricted diffusion |
Diffusion weighted imaging |
|
Neurological Inflammatory Infectious disease |
Grant E
Schaefer P
Sorensen AG
|
Asphyxia |
Early diffusion changes |
Diffusion weighted imaging |
|
Neurological |
Grant E
Jenkins BG
Schaefer P
|
Hepatic encephalopathy |
N-acetylaspartate (NAA) |
MRS |
|
Neurological |
Grant E
Jenkins BG
Schaefer P
|
Hepatic encephalopathy |
Glucose |
MRS |
|
Neurological |
Grant E
Jenkins BG
Schaefer P
|
Hepatic encephalopathy |
Choline |
MRS |
|
Neurological |
Grant E
Jenkins BG
Schaefer P
|
Hepatic encephalopathy |
Lactate |
MRS |
|
Neurological |
Grant E
Schaefer P
|
Infectious disease / -empyema -herpes virus -CJD
|
Restricted diffusion |
Diffusion weighted imaging |
|
Neurological Infectious disease |
Hadjikhani N
Rosen BR
Sorensen AG
|
Migraine |
Cortical spreading depression (CSD) |
Blood oxygen level dependent (BOLD) fMRI
|
Signal changes measured during visual aura |
Neurological |
| Hahn P |
Crohn's disease |
Bowel wall differentiation |
MR enteroclysis |
Use of experimental oral contrast Kaolin, locus bean gum, methylcellulose + Barium
|
Gastrointestinal Inflammatory |
| Hahn P |
Crohn's disease |
Inflammation |
MR enteroclysis |
Use of experimental oral contrast Kaolin, locus bean gum, methylcellulose + Barium
|
Gastrointestinal Inflammatory |
| Hahn P |
Inflammatory bowl disease (IBD)
|
Bowel wall thickening |
MRI |
Tissue FISP pulse sequence
|
Gastrointestinal Inflammatory |
| Hahn P |
Inflammatory bowl disease (IBD)
|
Peri-intestinal inflammation |
MRI |
Tissue FISP pulse sequence |
Gastrointestinal Inflammatory |
Hahn P
Prasad S
Saini S
|
Rectal carcinoma / recurrent |
Peri-rectal fat involvement |
MRI |
Predictor of high probability of local recurrence
|
Gastrointestinal Oncology / Neoplasm |
Hahn P
Prasad S
Saini S
|
Rectal carcinoma / recurrent |
Spiculated lymph node |
MRI |
Predictor of high probability of local recurrence
|
Gastrointestinal Oncology / Neoplasm |
Hahn P
Saini S
O'Neill MJ
Mueller P
|
Rectal carcinoma / advanced staging |
Infiltration of tunica muscularis Presence of positive nodes
|
MRI
Multidetector CT angiography (MDCT) US |
|
Gastrointestinal Oncology / Neoplasm |
Hahn P
Harisinghani M
Mueller P
Weissleder R
|
Hepatobiliary disorders |
Liver tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Gastrointestinal |
Hahn P
Mueller P
O’Neill MJ
Waltman A
|
Portal vein thrombosis |
Intravascular thrombus |
US
CT
MRI
Angiography |
|
Cardiology / Vascular Gastrointestinal |
Hahn P
Mueller P
O'Neill MJ |
Cholecystitis |
Gallstones |
US
CT
MRI |
|
Endocrine Inflammatory Infectious disease Gastrointestinal
|
| Hahn P Mueller P O'Neill MJ |
Cholecystitis |
Gallbladder wall thickening |
US CT MRI |
|
Endocrine Inflammatory Infectious disease Gastrointestinal
|
Hahn P
Mueller P
O'Neill MJ |
Cholelithiasis |
Gallstones |
US
CT
MRI |
|
Endocrine Inflammatory Gastrointestinal Metabolic
|
Hahn P
Mueller P
|
Biliary obstruction |
Biliary ductal dilatation |
US
CT
MRI
|
|
Gastrointestinal |
Hahn P
Mueller P
O'Neill MJ
|
Biliary parasitic disease |
Biliary ductal dilatation |
US CT MRI |
|
Gastrointestinal Infectious disease |
Hahn PF
Harisinghani M
Saini S
Weissleder R
|
Hepatic neoplasm / primary and secondary |
Lesion detection |
MRI |
Increased SNR and CNR with liver specific contrast agent GD-BOPTA and mangafodipir
|
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Mueller PR
O'Neill MJ
|
Prostate cancer |
Prostate volume |
US
CT
MRI |
|
Oncology / Neoplasm Genitourinary |
| Hahn PF O'Neill MJ Mueller P |
Choledo-cholithiasis |
Biliary ductal dilatation |
US
CT
MRI |
|
Endocrine Inflammatory Gastrointestinal Metabolic
|
Hahn PF
Halpern EF
Sahani D |
Hepatic focal nodular hyperplasia |
Liver tissue characterization |
MRI |
Using combined ferrumoxide / Gd-DPTA |
Oncology / Neoplasm Gastrointestinal Endocrine
|
Hahn PF
Halpern EF
Harisinghani M
Sahani D
|
Hepatocellular carcinoma |
Liver tissue characterization |
MRI |
Using combined ferrumoxide / Gd-DPTA |
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Mueller PR
Saini S
Sahani D
|
Hepatic neoplasm / primary and secondary |
Vascular architecture |
Multidector CT angiography (MDCTA) |
Presurgical treatment planning |
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Halpern EF
Sahani D
|
Cholangio-carcinoma |
Liver tissue characterization |
MRI |
Using combined ferrumoxide / Gd-DPTA |
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Sahani D |
Cirrhosis |
Caudate lobe enlargement |
MRI
CT |
Discrimination of alcohol from virus-induced cirrhosis
|
Gastrointestinal Infectious disease Inflammatory |
Hahn PF
Sahani D |
Cirrhosis |
Right posterior hepatic notch |
MRI
CT |
Discrimination of alcohol from virus-induced cirrhosis |
Gastrointestinal Infectious disease Inflammatory
|
Hahn PF
Mueller PR
O’Neill MJ
|
Benign prostatic hypertrophy |
Prostate volume |
US
CT
MRI |
|
Oncology / Neoplasm Genitourinary
|
Hahn PF
Harisinghani M
Mueller PR
O'Neill MJ
Weissleder R
|
Hepatic cysts |
Liver tissue characterization |
MRI
US |
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium |
Gastrointestinal |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Hepatic focal nodular hyperplasia |
Liver tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Oncology / Neoplasm Gastrointestinal Endocrine |
Hahn PF
Harisinghani M
Mueller PR
O'Neill MJ
|
Thyroid carcinoma |
Cystic nodal metastases |
US |
|
Oncology / Neoplasm Endocrine |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Splenic cysts |
Splenic tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide |
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Splenic neoplasm |
Splenic tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide |
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Harisinghani M
Mueller PR
Weissleder R
|
Hepatocellular carcinoma |
Liver tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide, mangafodipir trisodium
|
Oncology / Neoplasm Gastrointestinal |
Hahn PF
Harisinghani M
Mueller PR
Saini S
Weissleder R
|
Lymphatic extension of pelvic malignancy (gynecological oncology) |
Abnormal lymphatic uptake of tracer |
MRI |
MR Lymphangio-graphy using ultrasmall superpara-magnetic iron oxide
|
Oncology / Neoplasm Inflammatory |
Hahn PF
Harisinghani M
Mueller PF
O'Neill MJ
Saini S
Weissleder R
|
Hepatic hemangioma |
Liver tissue characterization |
MRI
US |
Using ultrasmall superpara-magnetic iron oxide OR Gd-based chelates |
Oncology / Neoplasm Gastrointestinal |
Halgren E
Stufflebeam SM
|
Epilepsy |
Seizure focus |
MEG / EEG |
|
Neurological |
Halpern EF
Saini S
Waltman AC
|
Pancreatic carcinoma |
Vascular involvement |
MRA |
Better predictor than conventional angiography |
Oncology / Neoplasm Gastrointestinal |
Halpern EF
Saini S
Waltman AC
|
Pancreatic carcinoma |
Portal Venous invasion |
MRA |
Better predictor than conventional angiography
|
Oncology / Neoplasm Gastrointestinal |
Harisinghani M
Weissleder R
|
Splenic trauma |
Splenic tissue characterization |
MRI |
Using ultrasmall superpara-magnetic iron oxide
|
Gastrointestinal Cardiology / Vascular |
Harisinghani M
Mueller PR
O’Neill MJ
Saini S
|
Adenopathy, lymphoma and metastatic disease |
Lesion volume |
US
CT
MRI |
Anatomic marker of disease presence |
Oncology / Neoplasm Genitourinary |
| Harris G |
Autism |
Frontal language area |
fMRI |
Abnormal fMRI activation of frontal language areas during semantic language tasks
|
Neurological |
| Harris G |
Breast neoplasm |
Tumor volume
|
MRI |
|
Oncology / Neoplasm |
| Harris G |
Huntington's disease |
Basal ganglia / putamen volume
|
MRI |
|
Neurological |
Harris G
Hoge R
Ostergaard L
Rosen B
Sorensen AG
Wald LL
|
Stroke |
Cerebral blood flow (CBF) |
MRI (combined Arterial spin labeling and Dynamic susceptibility contrast) CAPTIVE
|
MTT helps to stratify patients in clinical trials MR perfusion territory imaging |
Neurological Cardiology / Vascular |
Harris G
Hoge R
Ostergaard L
Rosen B
Sorensen AG
Wald LL
|
Stroke |
Cerebral blood volume (CBV) |
MRI (combined Arterial spin labeling and Dynamic susceptibility contrast) CAPTIVE |
MTT helps to stratify patients in clinical trials MR perfusion territory imaging |
Neurological Cardiology / Vascular |
Harris G
Hoge R
Ostergaard L
Rosen B
Sorensen AG
Wald LL
|
Stroke |
Mean transit time (MTT) |
MRI (combined Arterial spin labeling and Dynamic susceptibility contrast) CAPTIVE |
MTT helps to stratify patients in clinical trials MR perfusion territory imaging |
Neurological Cardiology / Vascular |
Harris G
Hoge R
Ostergaard L
Rosen B
Sorensen AG
Wald LL
|
Stroke |
Flow heterogeneity (FH) |
MRI (combined Arterial spin labeling and Dynamic susceptibility contrast) CAPTIVE |
MTT helps to stratify patients in clinical trials MR perfusion territory imaging |
Neurological Cardiology / Vascular |
Harris G
Mueller PR
O’Neill MJ
Saini S
|
Hepatic neoplasm / primary and secondary |
Lesion volume |
US
CT
RI |
Anatomic marker of disease presence |
Oncology / Neoplasm Gastrointestinal |
Harris G
Gonzalez RG
Sorensen AG
|
Alzheimer's disease |
Cerebral blood flow (CBF) |
SPECT
fMRI |
|
Neurological Metabolic |
Harris G
Gonzalez RG
Sorensen AG
|
Alzheimer's disease |
Cerebral blood volume (CBV) |
SPECT
fMRI |
|
Neurological Metabolic |
Harris G
Gonzalez RG
Sorensen AG
|
Alzheimer's disease |
Mean transit time (MTT) |
SPECT
fMRI |
|
Neurological Metabolic |
| Hoge R |
Alzheimer's disease |
Cerebral blood flow |
Perfusion weighted imaging / Arterial spin labeling
|
|
Neurological Metabolic |
| Hoge R |
Dementia |
Cerebral blood flow (CBF) |
MRI / arterial spin labeling
|
|
Neurological |
| Hoge R |
Parkinson’s disease |
Cerebral blood volume (CBV) |
MRI / Arterial spin labeling
|
|
Neurological |
| Hoge R |
Parkinson’s disease |
Cerebral blood flow (CBF) |
MRI / Arterial spin labeling
|
|
Neurological |
Hoge R
Kwong KK |
Epilepsy |
Hyperperfusion |
MRI / arterial spin labeling
|
|
Neurological |
Hoge R
Kwong KK |
Epilepsy |
Cerebral blood flow (CBF) |
MRI / arterial spin labeling
|
|
Neurological |
Huisman TA
Gonzalez RG
Schaefer P
Sorensen AG
|
Brain injury |
Restricted water mobility |
Diffusion weighted imaging Apparent diffusion constant |
Cytotoxic edema, vasogenic edema and diffuse axonal injury
|
Neurological |
Hunter G
Rosen B |
Hypertension |
Relative cerebral blood volume (rCBV) |
Dynamic susceptibility contrast MRI |
Using Gd-DTPA following L-arginine infusion
|
Neurological Cardiology / Vascular |
| Hunter GJ |
Lung neoplasm / primary and secondary
|
Lesion volume |
CT
MRI |
Anatomic marker of disease presence |
Oncology / Neoplasm |
| Hyman B |
Alzheimer's disease |
Entorhinal cortex |
MRI |
Can distinguish normal from mild AD with 93% accuracy
|
Neurological Metabolic |
| Hyman B |
Alzheimer's disease |
Anterior cingulate size and thickness |
MRI |
Can distinguish normal from mild AD with 93% accuracy
|
Neurological Metabolic |
| Hyman B |
Alzheimer's disease |
Neuritic (senile) plaque |
In vivo multiphoton microscopy |
Can use histochemical or immuno-fluorescence for amyloid B
|
Neurological Metabolic |
Jenkins B
Gonzalez RG
|
Multiple sclerosis |
Choline / sodium (NA) ratio Creatine / sodium (NA) ratio
|
MRS |
|
Neurological Inflammatory |
Jenkins B
Gonzalez RG
|
Multiple sclerosis |
Decreased N-acetylaspartate (NAA) |
MRS |
|
Neurological Inflammatory |
Jenkins B
|
Asphyxia |
Lactate : choline ratio |
MRS |
|
Neurological |
Jenkins B
Kennedy D
Rosas D
Rosen BR
|
Hodgkin's disease |
N-acetylaspartate (NAA) |
MRS |
|
Oncology / Neoplasm |
Jenkins B
Kosofsky B
Mandeville JB
Rosen B
|
Brain function / drugs of abuse |
Cerebral blood volume (CBV) |
fMRI |
Response to stimuli |
Neurological Metabolic |
Jenkins B
Kosofsky B
Mandeville JB
Rosen B
|
Brain function / drugs of abuse |
rCMRO2 |
fMRI |
Response to stimuli |
Neurological Metabolic |
Jenkins B
Rosen BR
Stufflebeam SM
|
Multiple sclerosis |
Comparative brainstem analysis |
MRI |
|
Neurological Inflammatory |
Jenkins B
Rosen BR
Stufflebeam SM
|
Multiple sclerosis |
MS plaque demylination |
MRI |
|
Neurological Inflammatory |
| Jenkins BG |
Epilepsy |
N-acetylaspartate (NAA) lateralization
|
MRS |
|
Neurological |
Jenkins BG
Rosen B
|
Huntington's disease |
N-acetylaspartate (NAA) |
MRS |
|
Neurological |
Jenkins BG
Rosen B
|
Huntington's disease |
Choline : creatine ratio |
MRS |
|
Neurological |
Jenkins BG
Rosen B
|
Huntington's disease |
Lactate |
MRS |
|
Neurological |
Jenkins BG
Kennedy D
Rosas HD
Rosen B
|
Neurodegenerative disorders |
Apparent diffusion constant (ADC) |
fMRI MRI / diffusion weighted imaging |
|
Neurological |
Jenkins BG
Kennedy D
Rosas HD
Rosen B
|
Neurodegenerative disorders |
Blood oxygen level depletion |
fMRI MRI / diffusion weighted imaging |
|
Neurological |
| Kennedy D |
Attention deficit hyperactivity disorder (ADHD)
|
Cortical thickness and asymmetry |
MRI (morphometry) |
|
Neurological |
| Kennedy D |
Obsessive compulsive disorder
|
Cortical thickness |
MRI (morphometry) |
|
Neurological |
Kennedy D
Lo E
Rosen B
|
Stroke |
Apparent diffusion constant (ADC) |
Diffusion weighted imaging fMRI MRI (morphometry)
|
|
Neurological Cardiology / Vascular |
Kennedy D
Lo E
Rosen B |
Stroke |
Relative cerebral blood flow index (rCBF) |
Diffusion weighted imaging fMRI MRI (morphometry)
|
|
Neurological Cardiology / Vascular |
Kennedy D
Rosen BR |
Obsessive compulsive disorder |
Whole brain morphometry |
MRI (morphometry) |
Findings include sig. less total white-matter and greater cortex and opercular volumes
|
Neurological |
| Kopans DB |
Breast neoplasm |
Presence of contralateral synchronous cancers |
MRI |
4 of 17 patients (24%) had contralateral cancer occult to physical exam, mammography and US
|
Oncology / Neoplasm |
| Kopans DB |
Breast neoplasm |
Regional blood flow and blood volume |
MRI |
Magnetic susceptibility-based contrast agent OR GD-DTPA with dynamic echo planar imaging
|
Oncology / Neoplasm |
| Kopans DB |
Breast neoplasm |
Microvessel density (MVD) |
MRI |
Magnetic susceptibility-based contrast agent OR GD-DTPA with dynamic echo planar imaging
|
Oncology / Neoplasm |
| Kopans DB |
Fibrocystic change |
Cyst composition / tissue characterization
|
US
CT
MRI
|
|
Oncology / Neoplasm |
Kuperberg G
Manoach D
Stufflebeam SM
Rosen B
|
Schizophrenia |
Specific regional uptake, target selection and functional activation |
fMRI |
Regional activation during cognitive paradigms |
Neurological |
Kwong KK
Weissleder R
|
CNS neoplasm / primary and secondary, presence and viability
|
Targeted cellular and molecular probes |
Optical MRI
PET |
Exogenous contrast agents Animal models |
Neurological Oncology / Neoplasm |
Mandeville JB
Rosen B
Tootell RBH
|
Visual process disorders |
Neuronal activation |
fMRI |
|
Neurological |
McLoud T
|
Pulmonary embolism |
Intravascular thrombus |
CT |
|
Cardiology / Vascular |
McLoud T
Shepard J
|
Alveolar pulmonary edema |
Pulmonary consolidation |
CT
MRI |
|
Cardiology / Vascular |
McLoud T
Shepard J
|
Interstitial pulmonary edema |
Increased pulmonary interstitial markings |
CT |
|
Inflammatory Cardiology / Vascular Infectious Disease
|
McLoud TC
Shepard J
|
Pneumonitis |
Pulmonary consolidation |
CT
MRI
Plain radiographs
|
|
Infectious disease Inflammatory |
McLoud TC
Shepard J
|
Pulmonary infection |
Increased pulmonary interstitial markings |
CT |
|
Infectious disease |
McLoud TC
Shepard J
|
Respiratory syncytial virus |
Ground-glass appearance |
CT |
|
Infectious disease |
McLoud TC
Shepard J
|
Respiratory syncytial virus |
Acute bronchial dilatation Wall thickening |
CT |
|
Infectious disease |
McLoud TC
Shepard J
|
Respiratory syncytial virus |
Opacities |
CT |
|
Infectious disease |
McLoud TC
Shepard J
|
Aveolar bronchial cell carcinoma |
Pulmonary consolidation |
CT
MRI |
|
Oncology / Neoplasm |
MMcLoud TC
Shepard J
|
Allergic drug reaction |
Increased pulmonary interstitial markings |
CT |
|
Endocrine Metabolic Inflammatory |
McLoud TC
Mueller PR
Shepard J
Weissleder R
|
Lymphangio- carcinomatosis |
Increased pulmonary interstitial markings |
CT |
|
Oncology / Neoplasm |
McLoud TC
Shepard J
|
Pneumonitis |
Pulmonary consolidation |
CT
MRI |
|
Infectious disease Inflammatory |
McLoud TC
Shepard J
|
Connective tissue disorders |
Increased pulmonary interstitial markings
|
CT |
|
Inflammatory |
Moore A Bogdanov AJ Weissleder R
|
Diabetes |
Directed molecular probes for beta cell mass |
MRI |
|
Metabolic Endocrine |
| Mueller P |
Intra-abdominal abscess |
Cyst composition / tissue characterization |
US
CT
MRI
|
|
Gastrointestinal Genitourinary Infectious disease
|
| Mueller PR |
Renal neoplasm / primary and secondary |
Cyst composition / tissue characterization
|
US
CT
MRI
|
|
Oncology / Neoplasm Genitourinary |
| Mueller PR |
Simple renal cysts |
Cyst composition / tissue characterization Soft tissue inflammation
|
US
CT
MRI
|
|
Oncology / Neoplasm Genitourinary |
| Mueller PR |
Simple renal cysts |
Soft tissue inflammation |
US
CT
MRI
|
|
Oncology / Neoplasm Genitourinary
|
Mueller PR
O’Neill MJ
Saini S
|
Renal neoplasm / primary and secondary |
Lesion volume |
US
CT
MRI
|
Anatomic marker of disease presence
|
Oncology / Neoplasm Genitourinary |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Anti-tumor antibody |
Optical |
Targeted Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Apoptosis Caspase-1 Caspase-3 |
Optical |
Active, stable Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Apoptosis Phosphatidylserine |
Optical |
Active, stable Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Cathepsin D |
Optical |
Active, stable Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Fluorescent proteins / exogenous |
Macroscopic fluorescence reflective imagine (FRI) Fluorescence molecular tomography (FMT)
|
Green fluorescence proteins (GFPs) Ds Red Hc Red |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Folate receptor |
Optical |
Targeted Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Glucose transporter |
Optical |
Targeted Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Matrix metalloproteinase-2 MMP-9 MMP-13 |
Optical |
Active, stable Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Neoplasm / primary and secondary |
Somatostatin receptor |
Optical |
Targeted Fluorochromes |
Oncology / Neoplasm |
Ntziachristos V
Weissleder R
|
Prostate cancer |
Prostate-specific antigens (PSA) |
Optical |
Active, stable Fluorochromes |
Oncology / Neoplasm |
| O'Neill MJ |
Bone fracture / healing and distraction osteogenesis wounds |
Bone fill score and penetration depth |
US |
Animal study Bone healing assessed by increased fill and decreased penetration depth
|
Musculoskeletal Metabolic |
| O'Neill MJ |
Breast neoplasm |
Microvascular blood volume |
US |
Microbubble contrast agents
|
Oncology / Neoplasm |
| O'Neill MJ |
Breast neoplasm |
Microvascular density |
US |
Microbubble contrast agents
|
Oncology / Neoplasm |
| O'Neill MJ |
Breast neoplasm |
Angiogenesis |
US |
Microbubble contrast agents
|
Oncology / Neoplasm |
| O'Neill MJ |
Ovarian neoplasm / presence and viability |
ROC curve analysis of 13 CT radiographic parameters |
CT |
Predictive model of relative success of surgical cytoreduction
|
Oncology / Neoplasm Genitourinary |
| O'Neill MJ Waltman A |
Vulnerable plaque |
Targeted mircobubble contrast agents |
Contrast enhanced US |
|
Neurological Cardiology / Vascular Inflammatory
|
O’Neill MJ
Waltman A
|
Deep venous thrombosis |
Intravascular thrombus |
US
MRI Angiography |
|
Cardiology / Vascular |
Palmer W
Rosenthal DI
|
Amyloid arthropathy / crystalline disease |
Periarticular erosion |
Plain radiographs
MRI |
|
Musculoskeletal Inflammatory Metabolic |
Palmer W
Rosenthal DI
|
Arthritis |
Joint space narrowing |
Plain radiographs |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Arthritis / inflammatory |
Synovial thickening |
MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Arthritis / septic |
Periarticular erosion |
Plain radiographs
MRI |
|
Infectious disease Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Bone fracture |
Cortical surface disruption |
Plain radiographs |
|
Musculoskeletal |
Palmer W
Rosenthal DI
|
Bone fracture |
Negative defect |
Plain radiographs |
|
Musculoskeletal |
Palmer W
Rosenthal DI
|
Bone fracture / healing |
Osseous bridging |
Plain radiographs
MRI
CT
|
|
Musculoskeletal Metabolic |
Palmer W
Rosenthal DI
|
Osteoarthritis |
Articular cartilage thickness |
Plain radiographs MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Pigmented villonodular synovitis |
Synovial thickening |
MRI |
|
Musculoskeletal Oncology / Neoplasm |
Palmer W
Rosenthal DI
|
Synovial chondromatosis |
Periarticular erosion |
Plain radiographs MRI |
|
Musculoskeletal Oncology / Neoplasm |
Palmer W
Rosenthal DI
|
Synovial cyst |
Cystic architecture / tissue characterization |
US
CT
MRI |
|
Musculoskeletal |
Palmer W
Rosenthal DI
|
Trauma |
Edema / change in signal intensity and apparent diffusion constant
|
MRI Diffusion weighted imaging |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Trauma |
Soft tissue inflammation |
MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Myopathy |
Soft tissue inflammation |
MRI |
|
Endocrine Inflammatory Infectious Disease Cardiology / Vascular
|
Palmer W
Rosenthal DI
|
Arthritis / inflammatory |
Articular cartilage thickness |
Plain radiographs
MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Arthritis / inflammatory |
Periarticular erosion |
Plain radiographs
MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Arthritis / rheumatoid |
Articular cartilage thickness |
Plain radiographs
MRI |
|
Musculoskeletal Inflammatory |
Palmer W
Rosenthal DI
|
Pigmented villonodular synovitis |
Periarticular erosion |
Plain radiographs
MRI |
|
Inflammatory Musculoskeletal |
Palmer W
Rosenthal DI
|
Arthritis / septic |
Cyst composition / tissue characterization |
PET |
|
Infectious disease Musculoskeletal Inflammatory
|
Palmer W
Rosenthal DI
|
Arthritis / septic |
Increased synovial glucose metabolism |
MRI |
|
Infectious disease Musculoskeletal Inflammatory
|
Palmer W
Rosenthal DI
|
Arthritis / septic |
Synovial thickening |
Plain radiographs
MRI |
|
Infectious disease Musculoskeletal Inflammatory
|
| Palmer WE |
Bone fracture |
Marrow edema |
MRI -T1 Diffusion weighted imaging / Apparent diffusion constant |
Impact fractures demonstrate prominent edema, distraction fractures exhibit minimal edema
|
Musculoskeletal |
| Palmer WE |
Bone fracture |
Water content |
MRI -T1 Diffusion weighted imaging / Apparent diffusion constant |
Impact fractures demonstrate prominent edema, distraction fractures exhibit minimal edema
|
Musculoskeletal |
| Palmer WE |
Cartilage abnormalities |
Articular cartilage and subchondral bone thickness |
MRI |
MR using fat-suppressed SPGR images
|
Musculoskeletal |
| Palmer WE |
Osteoarthritis |
Cartilage thickness |
Intra-articular Optical coherence topography
|
|
Musculoskeletal Inflammatory |
| Palmer WE |
Osteoarthritis |
Fibrillations |
Intra-articular Optical coherence topography
|
|
Musculoskeletal Inflammatory |
| Palmer WE |
Osteoarthritis |
Fibrosis |
Intra-articular Optical coherence topography
|
|
Musculoskeletal Inflammatory |
| Palmer WE |
Ankle injury |
Ligament tears |
MR arthrography |
Predicts sensitivity for ankle impingement syndromes
|
Musculoskeletal |
| Palmer WE |
Elbow injury / collateral ligament |
Partial thickness and full thickness tears
|
MR arthrography |
Distinguishes thickness of tears |
Musculoskeletal |
| Palmer WE |
Joint injury / general |
Osteochondral lesions |
MR arthrography |
Assesses the stability of lesions
|
Musculoskeletal |
| Palmer WE |
Rotator cuff injury |
Distribution and leakage of intra-articular administered contrast media
|
MR arthrography |
Distinguishes full from partial thickness tears |
Musculoskeletal |
| Palmer WE Rosenthal DI |
Neoplasm / primary and secondary |
Change in local tissue density or contrast enhancement |
CT
MRI |
Mutlicenter Trail with 367 patients - CT and MRI equally reliable for diagnosis
|
Musculoskeletal Oncology / Neoplasm |
| Palmer WE Rosenthal DI |
Osteoarticular allograft imaging |
Increasing periosteal and endosteal enhancement |
MRI |
3-4 months post allograft / represents vascular ingrowth and early skeletal repair
|
Musculoskeletal |
| Palmer WE Rosenberg AE Rosenthal DI |
Joint injury / hip and knee |
Spatial cartilage thickness |
Co-planar MRI |
MR using fat-saturated 3D spoiled gradient-echo images (SPGR)
|
Musculoskeletal |
| Palmer WE Rosenberg AE Rosenthal DI |
Joint injury / hip and knee |
Articular cartilage volume |
Co-planar MRI |
MR using fat-saturated 3D spoiled gradient-echo images (SPGR)
|
Musculoskeletal |
Prasad S
Sahani D
|
Cholangitis |
Ductal dilatation |
MRI |
MR cholangio- pancreatography |
Gastrointestinal Infectious disease Inflammatory
|
Prasad S
Sahani D
|
Cholangitis |
Biliary ductal dilatation |
MRI |
MR cholangio-pancreatography |
Gastrointestinal Infectious disease Inflammatory
|
Prasad S
Sahani D
|
Biliary stricture |
MR cholangio-pancreatography
|
MRI |
|
Gastrointestinal |
Prasad S
Sahani D
|
Pancreatic mass |
Contrast enhanced tissue characterization
|
MRI
cholangio -pancreatography
|
|
Oncology / Neoplasm Gastrointestinal |
Prasad S
Sahani D
|
Pancreatitis |
Ductal irregularity or obstruction |
MRI |
Visualized by MR cholanio-pancreatography (MRCP) |
Gastrointestinal Inflammatory Metabolic Infectious disease Endocrine
|
| Rosen B |
Dementia |
Blood oxygen level depletion (BOLD)
|
fMRI |
|
Neurological |
| Rosenthal DI |
AIDS wasting syndrome |
Body fat composition |
CT |
|
Endocrine Metabolic Musculoskeletal Infectious disease Gastrointestinal
|
| Rosenthal DI |
AIDS wasting syndrome / lipodystrophy |
Increased abdominal visceral fat associated with decreased bone mineral density
|
Quantitative CT Dual energy X-ray absorptiometry (DEXA) |
|
Endocrine Metabolic Musculoskeletal Infectious disease Gastrointestinal
|
| Rosenthal DI |
Ganglion cyst |
Cyst composition / tissue characterization |
US
CT
MRI
|
|
Musculoskeletal Inflammatory
|
| Rosenthal DI |
Obesity |
Body fat composition |
Quantitative
CT
MRI
US
|
|
Endocrine Metabolic Musculoskeletal Gastrointestinal
|
| Rosenthal DI |
Osseous neoplasm / primary and secondary |
Tissue characterization |
CT
MRI
|
|
Oncology / Neoplasm Musculoskeletal
|
| Rosenthal DI |
Osteopenia |
Bone mineral density |
Plain radiographs Dual energy X-ray absorptiometry (DEXA) CT
|
Must establish bone strength as well as density |
Endocrine Metabolic Musculoskeletal |
| Rosenthal DI |
Osteoporosis |
Bone mineral density |
Plain radiographs Dual energy X-ray absorptiometry (DEXA) CT
|
Must establish bone strength as well as density |
Endocrine Metabolic Musculoskeletal |
| Rosenthal DI |
Osteoporosis |
Microarchitecture deterioration |
Digital radiographs 3D microMRI 3D microCT
|
Fine element modeling (FEM) to predict mechanical properties
|
Musculoskeletal Metabolic |
| Rosenthal DI |
Osteoporosis |
Micro-architecture deterioration |
Digital radiographs 3D microMRI 3D microCT |
Fine element modeling (FEM) to predict mechanical properties
|
Musculoskeletal Metabolic |
| Rosenthal DI |
Osteoporosis |
Trabecular pore size |
MRI |
|
Musculoskeletal Metabolic
|
| Rosenthal DI |
Synovial cell sarcoma |
Cyst composition / tissue characterization |
US
CT
MRI
|
|
Oncology / Neoplasm Musculoskeletal
|
Sahani D
Prasad S
|
Calculus disease |
MR cholangio- pancreatography |
MRI |
|
Endocrine Gastrointestinal |
Schaechter J
Rosen BR
|
Stroke / recovery |
Cortical activation during sensorimotor tasks |
fMRI |
|
Neurological Cardiology / Vascular |
Tang Y
Weissleder R
|
CNS Neoplasm / schwannoma and neurofibromatosis
|
Tumor growth rate |
MRI |
Transgenic murine models of neurofibromatosis |
Neurological Oncology / Neoplasm |
| Torriani M |
HIV lipodystrophy syndrome
Diabetes (Type II)
Obesity
|
Intramyocellular lipid levels |
Proton MR spectroscopy |
|
Endocrine
Infectious disease
Metabolic
Musculoskeletal
|
| Wald LL |
Stroke |
Neuronal activation CMRO2 |
Arterial spin labeling MRI O2 15 PET Xenon Enhanced CT
|
|
Neurological Cardiology / Vascular |
| Waltman A |
Aortic aneurysm |
Vascular diameter and circumference |
US
C
MRI
|
|
Cardiology / Vascular |
| Waltman A |
Arterial embolism |
Intravascular thrombus |
CT
MRI Angiography
|
|
Cardiology / Vascular |
| Waltman A |
Dissection / peripheral |
Vascular lumen diameter |
CT
MRI Angiography
|
|
Cardiology / Vascular |
| Waltman A |
Iliac aneurysm |
Vascular diameter and circumference |
US
CT
MRI
|
|
Cardiology / Vascular |
| Weissleder |
Glioma |
Vascular volume fraction |
Optical |
|
Neurological Oncology / Neoplasm
|
| Weissleder R |
Glioma |
Tumor margin |
MRI |
Via ultra small particulate iron oxide (USPIO)
|
Neurological Oncology / Neoplasm |
| Weissleder R |
HIV
|
Directed molecular probes |
MRI
PET Optical
|
|
Infectious disease |
| Weissleder R |
Neoplasm / primary and secondary
|
Enzymatic activity |
Optical |
Rodent model |
Oncology / Neoplasm |
| Weissleder R |
Neoplasm / primary and secondary |
Human transferrin receptor |
MRI |
Receptor binding probe linking transferrin and monocrystalline iron oxide (Tf-MION)
|
Oncology / Neoplasm |
| Weissleder R |
Neoplasm / primary and secondary
|
Tumor mass |
Optical |
|
Oncology / Neoplasm |
| Weissleder R |
Parkinson’s disease
|
Directed molecular probes |
PET Optical |
|
Neurological |
| Weissleder R |
Pulmonary embolism |
Embolism volume |
MRI |
Via monocrystalline iron oxide nanoparticles (MION)
|
Cardiology / Vascular |
| Weissleder R |
Sarcoma |
Vascular volume fraction
|
Optical |
|
Oncology / Neoplasm |
| Weissleder R |
Vulnerable plaque |
Macrophage content |
Optical coherence topography
|
|
Neurological Cardiology / Vascular Inflammatory
|
| Weissleder R |
Vulnerable plaque |
Fibrous cap thickness |
Optical coherence topography |
|
Neurological Cardiology / Vascular Inflammatory
|
| Weissleder R |
Vulnerable plaque |
Plaque Type |
Optical coherence topography |
|
Neurological Cardiology / Vascular Inflammatory
|
